About Enhancer
| Enhancer ID: | E_01_0840 |
| Species: | human |
| Position : | chr2:9485612-9487612   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Lung cancer |
| Pubmed ID: | 33260349 |
| Enhancer experiment: | SiRNA transfection, Western blotting, chromatin immunoprecipitation assay, RNA isolation and RT-PCR |
| Enhancer experiment description: | Our results revealed that TGF-?-induced CTGF expression was weakened by ADAM17 small interfering RNA (ADAM17 siRNA), TNF-? processing inhibitor-0 (TAPI-0, an ADAM17 inhibitor), U0126 (an ERK inhibitor), RSK1 siRNA, and C/EBP? siRNA. |
About Target gene
| Target gene : | ADAM17 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Our results revealed that TGF-?-induced CTGF expression was weakened by ADAM17 small interfering RNA (ADAM17 siRNA), TNF-? processing inhibitor-0 (TAPI-0, an ADAM17 inhibitor), U0126 (an ERK inhibitor), RSK1 siRNA, and C/EBP? siRNA. |
About TF
| TF name : | -- |
| TF experiment: | siRNA???????????????????RNA???RT-PCR |
| TF experiment description: | Our results revealed that TGF-?-induced CTGF expression was weakened by ADAM17 small interfering RNA (ADAM17 siRNA), TNF-? processing inhibitor-0 (TAPI-0, an ADAM17 inhibitor), U0126 (an ERK inhibitor), RSK1 siRNA, and C/EBP? siRNA. |
About Function
| Enhancer function : | Our results revealed that TGF-?-induced CTGF expression was weakened by ADAM17 small interfering RNA (ADAM17 siRNA), TNF-? processing inhibitor-0 (TAPI-0, an ADAM17 inhibitor), U0126 (an ERK inhibitor), RSK1 siRNA, and C/EBP? siRNA. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Our results revealed that TGF-?-induced CTGF expression was weakened by ADAM17 small interfering RNA (ADAM17 siRNA), TNF-? processing inhibitor-0 (TAPI-0, an ADAM17 inhibitor), U0126 (an ERK inhibitor), RSK1 siRNA, and C/EBP? siRNA. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene