About Enhancer
| Enhancer ID: |
E_01_0817 |
| Species: |
human |
| Position :
|
chr19:4171328-4173328
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Ischemic stroke |
| Pubmed ID: |
33777677
|
| Enhancer experiment: |
SIRT6 protein purification and fluorescence cleavage assay (FDL), enzyme linked immunosorbent assay, Western blot analysis, chromatin immunoprecipitation (chip) assay, immunoprecipitation and immunoblotting |
| Enhancer experiment description: |
We designed a novel SIRT6 activator MDL-811 which remarkably inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RAW264. |
About Target gene
| Target gene : |
SIRT6 |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
We designed a novel SIRT6 activator MDL-811 which remarkably inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RAW264. |
About TF
| TF name : |
-- |
| TF experiment: |
SIRT6????????????FDL?,????????,???????,????????ChIP???,????????? |
| TF experiment description: |
We designed a novel SIRT6 activator MDL-811 which remarkably inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RAW264. |
About Function
| Enhancer function : |
We designed a novel SIRT6 activator MDL-811 which remarkably inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RAW264. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
We designed a novel SIRT6 activator MDL-811 which remarkably inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RAW264. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs