About Enhancer
| Enhancer ID: | E_01_0803 |
| Species: | human |
| Position : | chr1:116511683-116513683   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Multiple sclerosis (ms) |
| Pubmed ID: | 30006149 |
| Enhancer experiment: | Pull down assay, real time PCR, Western blot, statistical analysis, gene knockdown |
| Enhancer experiment description: | Abstract CD58 is expressed on the surface of antigen-presenting cells, including B-cells, and provides co- stimulation to regulatory T-cells (Treg) through CD2 receptor binding. Using bioinformatics and pull-down assay we found that the protective (C) rs1335532 allele created functional binding site for ASCL2 transcription factor, a target of the Wnt signaling pathway. |
About Target gene
| Target gene : | CD58 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Abstract CD58 is expressed on the surface of antigen-presenting cells, including B-cells, and provides co- stimulation to regulatory T-cells (Treg) through CD2 receptor binding. Using bioinformatics and pull-down assay we found that the protective (C) rs1335532 allele created functional binding site for ASCL2 transcription factor, a target of the Wnt signaling pathway. ;Abstract CD58 is expressed on the surface of antigen-presenting cells, including B-cells, and provides co- stimulation to regulatory T-cells (Treg) through CD2 receptor binding. Using bioinformatics and pull-down assay we found that the protective (C) rs1335532 allele created functional binding site for ASCL2 transcription factor, a target of the Wnt signaling pathway. |
About TF
| TF name : | ASCL2(ASH2,HASH2,MASH2,bHLHa45) |
| TF experiment: | Pull-Down Assay,Real-Time PCR,Western Blot,????,???? |
| TF experiment description: | Abstract CD58 is expressed on the surface of antigen-presenting cells, including B-cells, and provides co- stimulation to regulatory T-cells (Treg) through CD2 receptor binding. Using bioinformatics and pull-down assay we found that the protective (C) rs1335532 allele created functional binding site for ASCL2 transcription factor, a target of the Wnt signaling pathway. ;Abstract CD58 is expressed on the surface of antigen-presenting cells, including B-cells, and provides co- stimulation to regulatory T-cells (Treg) through CD2 receptor binding. Using bioinformatics and pull-down assay we found that the protective (C) rs1335532 allele created functional binding site for ASCL2 transcription factor, a target of the Wnt signaling pathway. |
About Function
| Enhancer function : | Abstract CD58 is expressed on the surface of antigen-presenting cells, including B-cells, and provides co- stimulation to regulatory T-cells (Treg) through CD2 receptor binding. Using bioinformatics and pull-down assay we found that the protective (C) rs1335532 allele created functional binding site for ASCL2 transcription factor, a target of the Wnt signaling pathway. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Abstract CD58 is expressed on the surface of antigen-presenting cells, including B-cells, and provides co- stimulation to regulatory T-cells (Treg) through CD2 receptor binding. Using bioinformatics and pull-down assay we found that the protective (C) rs1335532 allele created functional binding site for ASCL2 transcription factor, a target of the Wnt signaling pathway. |
About SNP
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene