About Enhancer
| Enhancer ID: | E_01_0796 |
| Species: | human |
| Position : | chr16:4253924-4255924   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Hepatocellular carcinoma |
| Pubmed ID: | 30026867 |
| Enhancer experiment: | Western blot, immunohistochemistry, chip qPCR, flow cytometry, statistical analysis |
| Enhancer experiment description: | It has been reported that the transcription factor activating enhancer-binding protein 4 (TFAP4) is upregulated and associated with an aggressive phenotype in several cancers. Mechanistically, we demonstrated that TFAP4 played an important role in activating Wnt/?-catenin signaling by directly binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1). |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | It has been reported that the transcription factor activating enhancer-binding protein 4 (TFAP4) is upregulated and associated with an aggressive phenotype in several cancers. Mechanistically, we demonstrated that TFAP4 played an important role in activating Wnt/?-catenin signaling by directly binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1). ;It has been reported that the transcription factor activating enhancer-binding protein 4 (TFAP4) is upregulated and associated with an aggressive phenotype in several cancers. Mechanistically, we demonstrated that TFAP4 played an important role in activating Wnt/?-catenin signaling by directly binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1). |
About TF
| TF name : | TFAP4LEF1(LEF-1,TCF10,TCF1ALPHA,TCF7L3) |
| TF experiment: | western blot,Immunohistochemistry,ChIP-qPCR,?????,???? |
| TF experiment description: | It has been reported that the transcription factor activating enhancer-binding protein 4 (TFAP4) is upregulated and associated with an aggressive phenotype in several cancers. Mechanistically, we demonstrated that TFAP4 played an important role in activating Wnt/?-catenin signaling by directly binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1). ;It has been reported that the transcription factor activating enhancer-binding protein 4 (TFAP4) is upregulated and associated with an aggressive phenotype in several cancers. Mechanistically, we demonstrated that TFAP4 played an important role in activating Wnt/?-catenin signaling by directly binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1). |
About Function
| Enhancer function : | It has been reported that the transcription factor activating enhancer-binding protein 4 (TFAP4) is upregulated and associated with an aggressive phenotype in several cancers. Mechanistically, we demonstrated that TFAP4 played an important role in activating Wnt/?-catenin signaling by directly binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
It has been reported that the transcription factor activating enhancer-binding protein 4 (TFAP4) is upregulated and associated with an aggressive phenotype in several cancers. Mechanistically, we demonstrated that TFAP4 played an important role in activating Wnt/?-catenin signaling by directly binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1). |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene