About Enhancer
| Enhancer ID: | E_01_0785 |
| Species: | human |
| Position : | chr10:128093460-128095460   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Glioblastoma |
| Pubmed ID: | 30054476 |
| Enhancer experiment: | Western blot, real-time PCR, RNA SEQ, MS-PCR, chip SEQ, statistical analysis |
| Enhancer experiment description: | MGMT expression can be silenced by the methylation of a promoter/enhancer (P/E) region, which contains a promoter and a 59 bp cis-acting enhancer element that spans the first exon intron boundary of MGMT gene4. |
About Target gene
| Target gene : | MKI67,MGMT(MGMT) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | MGMT expression can be silenced by the methylation of a promoter/enhancer (P/E) region, which contains a promoter and a 59 bp cis-acting enhancer element that spans the first exon intron boundary of MGMT gene4. ;MGMT expression can be silenced by the methylation of a promoter/enhancer (P/E) region, which contains a promoter and a 59 bp cis-acting enhancer element that spans the first exon intron boundary of MGMT gene4. |
About TF
| TF name : | -- |
| TF experiment: | Western blot,real-time PCR,RNA-seq,MS-PCR,ChIP-seq,???? |
| TF experiment description: | MGMT expression can be silenced by the methylation of a promoter/enhancer (P/E) region, which contains a promoter and a 59 bp cis-acting enhancer element that spans the first exon intron boundary of MGMT gene4. ;MGMT expression can be silenced by the methylation of a promoter/enhancer (P/E) region, which contains a promoter and a 59 bp cis-acting enhancer element that spans the first exon intron boundary of MGMT gene4. |
About Function
| Enhancer function : | MGMT expression can be silenced by the methylation of a promoter/enhancer (P/E) region, which contains a promoter and a 59 bp cis-acting enhancer element that spans the first exon intron boundary of MGMT gene4. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
MGMT expression can be silenced by the methylation of a promoter/enhancer (P/E) region, which contains a promoter and a 59 bp cis-acting enhancer element that spans the first exon intron boundary of MGMT gene4. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene