About Enhancer
| Enhancer ID: | E_01_0778 |
| Species: | human |
| Position : | chr20:62793633-62795633   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Prostatic cancer |
| Pubmed ID: | 30076933 |
| Enhancer experiment: | QPCR, Western blot, hat assay, statistical analysis |
| Enhancer experiment description: | This study showed that MRG domain binding protein (MRGBP) accelerated AR-mediated transactivation. MRGBP increased the expression of certain AR target genes, including KLK3 and TMPRSS2, and it associated with AR binding regions of these genes during androgen treatment. |
About Target gene
| Target gene : | MRGBP,KLK3(APS,KLK2A1,PSA,hK3) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | This study showed that MRG domain binding protein (MRGBP) accelerated AR-mediated transactivation. MRGBP increased the expression of certain AR target genes, including KLK3 and TMPRSS2, and it associated with AR binding regions of these genes during androgen treatment. ;This study showed that MRG domain binding protein (MRGBP) accelerated AR-mediated transactivation. MRGBP increased the expression of certain AR target genes, including KLK3 and TMPRSS2, and it associated with AR binding regions of these genes during androgen treatment. ;This study showed that MRG domain binding protein (MRGBP) accelerated AR-mediated transactivation. MRGBP increased the expression of certain AR target genes, including KLK3 and TMPRSS2, and it associated with AR binding regions of these genes during androgen treatment. |
About TF
| TF name : | TMPRSS2 |
| TF experiment: | qPCR,western blot,HAT assay,???? |
| TF experiment description: | This study showed that MRG domain binding protein (MRGBP) accelerated AR-mediated transactivation. MRGBP increased the expression of certain AR target genes, including KLK3 and TMPRSS2, and it associated with AR binding regions of these genes during androgen treatment. ;This study showed that MRG domain binding protein (MRGBP) accelerated AR-mediated transactivation. MRGBP increased the expression of certain AR target genes, including KLK3 and TMPRSS2, and it associated with AR binding regions of these genes during androgen treatment. ;This study showed that MRG domain binding protein (MRGBP) accelerated AR-mediated transactivation. MRGBP increased the expression of certain AR target genes, including KLK3 and TMPRSS2, and it associated with AR binding regions of these genes during androgen treatment. |
About Function
| Enhancer function : | This study showed that MRG domain binding protein (MRGBP) accelerated AR-mediated transactivation. MRGBP increased the expression of certain AR target genes, including KLK3 and TMPRSS2, and it associated with AR binding regions of these genes during androgen treatment. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
This study showed that MRG domain binding protein (MRGBP) accelerated AR-mediated transactivation. MRGBP increased the expression of certain AR target genes, including KLK3 and TMPRSS2, and it associated with AR binding regions of these genes during androgen treatment. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TMPRSS2 | Coregulation of Androgen receptor activity | pid | 61 |
| TMPRSS2 | Regulation of Androgen receptor activity | pid | 54 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene