About Enhancer
| Enhancer ID: | E_01_0758 |
| Species: | human |
| Position : | chr12:102954801-102956801   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Lung adenocarcinoma, lung squamous cell carcinoma |
| Pubmed ID: | 30121393 |
| Enhancer experiment: | RNA-seq,RT-PCR |
| Enhancer experiment description: | ABSTRACT Introduction: A subgroup of lung adenocarcinoma shows neuroendocrine differentiation and expression of achaete- scute family bHLH transcription factor 1 (ASCL1), common to high-grade neuroendocrine tumors, small-cell lung can- cer and large cell neuroendocrine carcinoma. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | ABSTRACT Introduction: A subgroup of lung adenocarcinoma shows neuroendocrine differentiation and expression of achaete- scute family bHLH transcription factor 1 (ASCL1), common to high-grade neuroendocrine tumors, small-cell lung can- cer and large cell neuroendocrine carcinoma. |
About TF
| TF name : | ASCL1(AI225900,ASH1,Mash1,bHLHa46) |
| TF experiment: | RNA-seq,RT-PCR |
| TF experiment description: | ABSTRACT Introduction: A subgroup of lung adenocarcinoma shows neuroendocrine differentiation and expression of achaete- scute family bHLH transcription factor 1 (ASCL1), common to high-grade neuroendocrine tumors, small-cell lung can- cer and large cell neuroendocrine carcinoma. |
About Function
| Enhancer function : | ABSTRACT Introduction: A subgroup of lung adenocarcinoma shows neuroendocrine differentiation and expression of achaete- scute family bHLH transcription factor 1 (ASCL1), common to high-grade neuroendocrine tumors, small-cell lung can- cer and large cell neuroendocrine carcinoma. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
ABSTRACT Introduction: A subgroup of lung adenocarcinoma shows neuroendocrine differentiation and expression of achaete- scute family bHLH transcription factor 1 (ASCL1), common to high-grade neuroendocrine tumors, small-cell lung can- cer and large cell neuroendocrine carcinoma. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ASCL1 | Notch-mediated HES/HEY network | pid | 48 |
| ASCL1 | Notch | netpath | 76 |
| ASCL1 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| ASCL1 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene