About Enhancer
| Enhancer ID: | E_01_0753 |
| Species: | human |
| Position : | chr20:47206665-47208665   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 30134174 |
| Enhancer experiment: | Chip SEQ, QRT PCR, Weston blot, analysis of immunoprecipitation reactions, statistical analysis |
| Enhancer experiment description: | Physiologically, we further show that the ZMYND8 P-TEFb complex-mediated transcriptional activation is required for All-Trans Retinoic Acid (ATRA)-mediated differentiation of neuronal precursor cells. Through its interaction with KDM5C, ZMYND8 also suppresses enhancer over-expression by maintaining H3K4me1 enhancer signature (Shen et al., 2016). Among all the positive regulators of transcription, human P-TEFb complex, a heterodimer of CyclinT1/T2 and cyclin-dependent kinase 9 (CDK9) (Peng et al., 1998), plays a major role in activating target gene expression. |
About Target gene
| Target gene : | ZMYND8 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Physiologically, we further show that the ZMYND8 P-TEFb complex-mediated transcriptional activation is required for All-Trans Retinoic Acid (ATRA)-mediated differentiation of neuronal precursor cells. Through its interaction with KDM5C, ZMYND8 also suppresses enhancer over-expression by maintaining H3K4me1 enhancer signature (Shen et al., 2016). Among all the positive regulators of transcription, human P-TEFb complex, a heterodimer of CyclinT1/T2 and cyclin-dependent kinase 9 (CDK9) (Peng et al., 1998), plays a major role in activating target gene expression.;Physiologically, we further show that the ZMYND8 P-TEFb complex-mediated transcriptional activation is required for All-Trans Retinoic Acid (ATRA)-mediated differentiation of neuronal precursor cells. Through its interaction with KDM5C, ZMYND8 also suppresses enhancer over-expression by maintaining H3K4me1 enhancer signature (Shen et al., 2016). Among all the positive regulators of transcription, human P-TEFb complex, a heterodimer of CyclinT1/T2 and cyclin-dependent kinase 9 (CDK9) (Peng et al., 1998), plays a major role in activating target gene expression.;Physiologically, we further show that the ZMYND8 P-TEFb complex-mediated transcriptional activation is required for All-Trans Retinoic Acid (ATRA)-mediated differentiation of neuronal precursor cells. Through its interaction with KDM5C, ZMYND8 also suppresses enhancer over-expression by maintaining H3K4me1 enhancer signature (Shen et al., 2016). Among all the positive regulators of transcription, human P-TEFb complex, a heterodimer of CyclinT1/T2 and cyclin-dependent kinase 9 (CDK9) (Peng et al., 1998), plays a major role in activating target gene expression. |
About TF
| TF name : | KDM5CCDK9(C-2k,CDC2L4,CTK1,PITALRE,TAK) |
| TF experiment: | ChIP-seq,qRT-PCR,weston blot,????????,???? |
| TF experiment description: | Physiologically, we further show that the ZMYND8 P-TEFb complex-mediated transcriptional activation is required for All-Trans Retinoic Acid (ATRA)-mediated differentiation of neuronal precursor cells. Through its interaction with KDM5C, ZMYND8 also suppresses enhancer over-expression by maintaining H3K4me1 enhancer signature (Shen et al., 2016). Among all the positive regulators of transcription, human P-TEFb complex, a heterodimer of CyclinT1/T2 and cyclin-dependent kinase 9 (CDK9) (Peng et al., 1998), plays a major role in activating target gene expression.;Physiologically, we further show that the ZMYND8 P-TEFb complex-mediated transcriptional activation is required for All-Trans Retinoic Acid (ATRA)-mediated differentiation of neuronal precursor cells. Through its interaction with KDM5C, ZMYND8 also suppresses enhancer over-expression by maintaining H3K4me1 enhancer signature (Shen et al., 2016). Among all the positive regulators of transcription, human P-TEFb complex, a heterodimer of CyclinT1/T2 and cyclin-dependent kinase 9 (CDK9) (Peng et al., 1998), plays a major role in activating target gene expression.;Physiologically, we further show that the ZMYND8 P-TEFb complex-mediated transcriptional activation is required for All-Trans Retinoic Acid (ATRA)-mediated differentiation of neuronal precursor cells. Through its interaction with KDM5C, ZMYND8 also suppresses enhancer over-expression by maintaining H3K4me1 enhancer signature (Shen et al., 2016). Among all the positive regulators of transcription, human P-TEFb complex, a heterodimer of CyclinT1/T2 and cyclin-dependent kinase 9 (CDK9) (Peng et al., 1998), plays a major role in activating target gene expression. |
About Function
| Enhancer function : | Physiologically, we further show that the ZMYND8 P-TEFb complex-mediated transcriptional activation is required for All-Trans Retinoic Acid (ATRA)-mediated differentiation of neuronal precursor cells. Through its interaction with KDM5C, ZMYND8 also suppresses enhancer over-expression by maintaining H3K4me1 enhancer signature (Shen et al., 2016). Among all the positive regulators of transcription, human P-TEFb complex, a heterodimer of CyclinT1/T2 and cyclin-dependent kinase 9 (CDK9) (Peng et al., 1998), plays a major role in activating target gene expression. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Physiologically, we further show that the ZMYND8 P-TEFb complex-mediated transcriptional activation is required for All-Trans Retinoic Acid (ATRA)-mediated differentiation of neuronal precursor cells. Through its interaction with KDM5C, ZMYND8 also suppresses enhancer over-expression by maintaining H3K4me1 enhancer signature (Shen et al., 2016). Among all the positive regulators of transcription, human P-TEFb complex, a heterodimer of CyclinT1/T2 and cyclin-dependent kinase 9 (CDK9) (Peng et al., 1998), plays a major role in activating target gene expression. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene