About Enhancer
| Enhancer ID: | E_01_0752 |
| Species: | human |
| Position : | chr13:30453788-30455788   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Inflammation |
| Pubmed ID: | 30134807 |
| Enhancer experiment: | Statistical analysis, ELISA method |
| Enhancer experiment description: | Background High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. However, full length HMGB1 and ?30 HMGB1 formed complexes with PGN, a known TLR2 ligand, and synergistically potentiated the inflammatory response in PBMCs. |
About Target gene
| Target gene : | HMGB1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Background High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. However, full length HMGB1 and ?30 HMGB1 formed complexes with PGN, a known TLR2 ligand, and synergistically potentiated the inflammatory response in PBMCs.;Background High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. However, full length HMGB1 and ?30 HMGB1 formed complexes with PGN, a known TLR2 ligand, and synergistically potentiated the inflammatory response in PBMCs. |
About TF
| TF name : | TLR2 |
| TF experiment: | ????,elisa? |
| TF experiment description: | Background High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. However, full length HMGB1 and ?30 HMGB1 formed complexes with PGN, a known TLR2 ligand, and synergistically potentiated the inflammatory response in PBMCs.;Background High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. However, full length HMGB1 and ?30 HMGB1 formed complexes with PGN, a known TLR2 ligand, and synergistically potentiated the inflammatory response in PBMCs. |
About Function
| Enhancer function : | Background High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. However, full length HMGB1 and ?30 HMGB1 formed complexes with PGN, a known TLR2 ligand, and synergistically potentiated the inflammatory response in PBMCs. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Background High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. However, full length HMGB1 and ?30 HMGB1 formed complexes with PGN, a known TLR2 ligand, and synergistically potentiated the inflammatory response in PBMCs. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TLR2 | Beta defensins | reactome | 46 |
| TLR2 | Endogenous TLR signaling | pid | 26 |
| TLR2 | IRAK4 deficiency (TLR2/4) | reactome | 11 |
| TLR2 | MyD88 deficiency (TLR2/4) | reactome | 11 |
| TLR2 | MyD88:Mal cascade initiated on plasma membrane | reactome | 19 |
| TLR2 | Toll receptor signaling pathway | panther | 44 |
| TLR2 | Phagosome | kegg | 154 |
| TLR2 | Toll-like receptor signaling pathway | kegg | 100 |
| TLR2 | Leishmaniasis | kegg | 71 |
| TLR2 | Chagas disease | kegg | 103 |
| TLR2 | Malaria | kegg | 50 |
| TLR2 | Toxoplasmosis | kegg | 131 |
| TLR2 | Amoebiasis | kegg | 103 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene