About Enhancer
| Enhancer ID: | E_01_0748 |
| Species: | human |
| Position : | chr6:151653890-151655890   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Mammary cancer |
| Pubmed ID: | 30145202 |
| Enhancer experiment: | qPCR,weston blot,GRO-seq?DNA-seq,RNA-seq,ChIP-seq |
| Enhancer experiment description: | Abstract Breast cancer is the most prevalent type of malignancy in women with ~1.7 million new cases diagnosed annually, of which the majority express ER? (ESR1), a ligand- dependent transcription factor. Here, we show that CUTE controls CUEDC1 expression, and that this interaction is essential for ER?-mediated cell proliferation. |
About Target gene
| Target gene : | CUEDC1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Abstract Breast cancer is the most prevalent type of malignancy in women with ~1.7 million new cases diagnosed annually, of which the majority express ER? (ESR1), a ligand- dependent transcription factor. Here, we show that CUTE controls CUEDC1 expression, and that this interaction is essential for ER?-mediated cell proliferation.;Abstract Breast cancer is the most prevalent type of malignancy in women with ~1.7 million new cases diagnosed annually, of which the majority express ER? (ESR1), a ligand- dependent transcription factor. Here, we show that CUTE controls CUEDC1 expression, and that this interaction is essential for ER?-mediated cell proliferation. |
About TF
| TF name : | ESR1(ER,ESR,ESRA,ESTRR,Era,NR3A1) |
| TF experiment: | qPCR,weston blot,GRO-seq?DNA-seq,RNA-seq,ChIP-seq |
| TF experiment description: | Abstract Breast cancer is the most prevalent type of malignancy in women with ~1.7 million new cases diagnosed annually, of which the majority express ER? (ESR1), a ligand- dependent transcription factor. Here, we show that CUTE controls CUEDC1 expression, and that this interaction is essential for ER?-mediated cell proliferation.;Abstract Breast cancer is the most prevalent type of malignancy in women with ~1.7 million new cases diagnosed annually, of which the majority express ER? (ESR1), a ligand- dependent transcription factor. Here, we show that CUTE controls CUEDC1 expression, and that this interaction is essential for ER?-mediated cell proliferation. |
About Function
| Enhancer function : | Abstract Breast cancer is the most prevalent type of malignancy in women with ~1.7 million new cases diagnosed annually, of which the majority express ER? (ESR1), a ligand- dependent transcription factor. Here, we show that CUTE controls CUEDC1 expression, and that this interaction is essential for ER?-mediated cell proliferation. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Abstract Breast cancer is the most prevalent type of malignancy in women with ~1.7 million new cases diagnosed annually, of which the majority express ER? (ESR1), a ligand- dependent transcription factor. Here, we show that CUTE controls CUEDC1 expression, and that this interaction is essential for ER?-mediated cell proliferation. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene