About Enhancer
| Enhancer ID: | E_01_0747 |
| Species: | human |
| Position : | chr1:161763665-161765665   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Cancer, diabetes |
| Pubmed ID: | 30145643 |
| Enhancer experiment: | Weston blot, statistical analysis |
| Enhancer experiment description: | The UPR is mediated by three main sensors embedded in the ER membrane Activating transcription factor 6 (ATF6), Inositol-requiring enzyme 1 (IRE1) and Protein Kinase R-like ER kinase (PERK) [3]. Activated IRE1 splices an intron from XBP1 mRNA allowing it to be translated into a functional transcription factor (XBP1s), which has several downstream targets involved in the UPR [11,12]. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | The UPR is mediated by three main sensors embedded in the ER membrane Activating transcription factor 6 (ATF6), Inositol-requiring enzyme 1 (IRE1) and Protein Kinase R-like ER kinase (PERK) [3]. Activated IRE1 splices an intron from XBP1 mRNA allowing it to be translated into a functional transcription factor (XBP1s), which has several downstream targets involved in the UPR [11,12]. ;The UPR is mediated by three main sensors embedded in the ER membrane Activating transcription factor 6 (ATF6), Inositol-requiring enzyme 1 (IRE1) and Protein Kinase R-like ER kinase (PERK) [3]. Activated IRE1 splices an intron from XBP1 mRNA allowing it to be translated into a functional transcription factor (XBP1s), which has several downstream targets involved in the UPR [11,12]. |
About TF
| TF name : | ATF6XBP1 |
| TF experiment: | weston blot,???? |
| TF experiment description: | The UPR is mediated by three main sensors embedded in the ER membrane Activating transcription factor 6 (ATF6), Inositol-requiring enzyme 1 (IRE1) and Protein Kinase R-like ER kinase (PERK) [3]. Activated IRE1 splices an intron from XBP1 mRNA allowing it to be translated into a functional transcription factor (XBP1s), which has several downstream targets involved in the UPR [11,12]. ;The UPR is mediated by three main sensors embedded in the ER membrane Activating transcription factor 6 (ATF6), Inositol-requiring enzyme 1 (IRE1) and Protein Kinase R-like ER kinase (PERK) [3]. Activated IRE1 splices an intron from XBP1 mRNA allowing it to be translated into a functional transcription factor (XBP1s), which has several downstream targets involved in the UPR [11,12]. |
About Function
| Enhancer function : | The UPR is mediated by three main sensors embedded in the ER membrane Activating transcription factor 6 (ATF6), Inositol-requiring enzyme 1 (IRE1) and Protein Kinase R-like ER kinase (PERK) [3]. Activated IRE1 splices an intron from XBP1 mRNA allowing it to be translated into a functional transcription factor (XBP1s), which has several downstream targets involved in the UPR [11,12]. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
The UPR is mediated by three main sensors embedded in the ER membrane Activating transcription factor 6 (ATF6), Inositol-requiring enzyme 1 (IRE1) and Protein Kinase R-like ER kinase (PERK) [3]. Activated IRE1 splices an intron from XBP1 mRNA allowing it to be translated into a functional transcription factor (XBP1s), which has several downstream targets involved in the UPR [11,12]. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ATF6 | Apoptosis signaling pathway | panther | 104 |
| ATF6 | ATF4 activates genes | reactome | 25 |
| ATF6 | ATF6-alpha activates chaperone genes | reactome | 10 |
| ATF6 | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| ATF6 | Protein processing in endoplasmic reticulum | kegg | 166 |
| ATF6 | Alzheimer's disease | kegg | 167 |
| ATF6 | Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330 | wikipathways | 6 |
| ATF6 | Hs_Sterol_Regulatory_Element-Binding_Proteins_(SREBP)_signalling_WP1982_90425 | wikipathways | 15 |
| XBP1 | ATF6-alpha activates chaperone genes | reactome | 10 |
| XBP1 | FOXA1 transcription factor network | pid | 45 |
| XBP1 | Validated nuclear estrogen receptor alpha network | pid | 65 |
| XBP1 | XBP1(S) activates chaperone genes | reactome | 53 |
| XBP1 | Protein processing in endoplasmic reticulum | kegg | 166 |
| XBP1 | Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330 | wikipathways | 6 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene