About Enhancer

Enhancer ID: E_01_0715
Species: human
Position : chr13:26129178-26131178
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Colorectal cancer
Pubmed ID:  29374067
Enhancer experiment: DNA extraction,DNA copy number Real-time PCR,Co-immunoprecipitation,mass spectrometry,Ubiquitination Assay,Luciferase reporter activity analysis
Enhancer experiment description: TLE3 expression abolished the oncogenic effects of RNF6,and RNF6 plays a pivotal oncogenic role in colorectal tumorigenesis.

About Target gene

Target gene : RNF6
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: TLE3 expression abolished the oncogenic effects of RNF6,and RNF6 plays a pivotal oncogenic role in colorectal tumorigenesis. ;TLE3 expression abolished the oncogenic effects of RNF6,and RNF6 plays a pivotal oncogenic role in colorectal tumorigenesis.

About TF

TF name : TLE3
TF experiment: DNA extraction,DNA copy number Real-time PCR,Co-immunoprecipitation,mass spectrometry,Ubiquitination Assay,Luciferase reporter activity analysis
TF experiment description: TLE3 expression abolished the oncogenic effects of RNF6,and RNF6 plays a pivotal oncogenic role in colorectal tumorigenesis. ;TLE3 expression abolished the oncogenic effects of RNF6,and RNF6 plays a pivotal oncogenic role in colorectal tumorigenesis.

About Function

Enhancer function : TLE3 expression abolished the oncogenic effects of RNF6,and RNF6 plays a pivotal oncogenic role in colorectal tumorigenesis.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 TLE3 expression abolished the oncogenic effects of RNF6,and RNF6 plays a pivotal oncogenic role in colorectal tumorigenesis.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
TLE3 Deactivation of the beta-catenin transactivating complex reactome 42
TLE3 Formation of the beta-catenin:TCF transactivating complex reactome 88
TLE3 Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) inoh 21
TLE3 NOTCH1 Intracellular Domain Regulates Transcription reactome 47
TLE3 Repression of WNT target genes reactome 14
TLE3 Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 47
TLE3 Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 47
TLE3 Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 47
TLE3 Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
TLE3 Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 47
TLE3 Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
TLE3 Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 8
TLE3 Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 8
TLE3 Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 8
TLE3 Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 8
TLE3 Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 8
TLE3 Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 8
TLE3 Wnt signaling pathway panther 250
TLE3 Hs_White_fat_cell_differentiation_WP3946_90940 wikipathways 30

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs