About Enhancer
| Enhancer ID: | E_01_0686 |
| Species: | human |
| Position : | chr16:50739227-50741227   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Rheumatoid arthritis |
| Pubmed ID: | 30285829 |
| Enhancer experiment: | Immunohistochemistry (IHC),Immunofluorescence (IF) staining,RT-PCR,Western blot,ELISA,Cell proliferation assay,y flow cytometry |
| Enhancer experiment description: | Via its regulation of NF-?B activation, CYLD may be involved in the pathogenesis of synovial inflammation in RA as well as in the pro-inflammatory effects and hyperproliferation of RA-FLSs. CYLD may therefore provide a potential target for the treatment of RA. |
About Target gene
| Target gene : | CYLD |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Via its regulation of NF-?B activation, CYLD may be involved in the pathogenesis of synovial inflammation in RA as well as in the pro-inflammatory effects and hyperproliferation of RA-FLSs. CYLD may therefore provide a potential target for the treatment of RA. |
About TF
| TF name : | -- |
| TF experiment: | Immunohistochemistry (IHC),Immunofluorescence (IF) staining,RT-PCR,Western blot,ELISA,Cell proliferation assay,y flow cytometry |
| TF experiment description: | Via its regulation of NF-?B activation, CYLD may be involved in the pathogenesis of synovial inflammation in RA as well as in the pro-inflammatory effects and hyperproliferation of RA-FLSs. CYLD may therefore provide a potential target for the treatment of RA. |
About Function
| Enhancer function : | Via its regulation of NF-?B activation, CYLD may be involved in the pathogenesis of synovial inflammation in RA as well as in the pro-inflammatory effects and hyperproliferation of RA-FLSs. CYLD may therefore provide a potential target for the treatment of RA. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Via its regulation of NF-?B activation, CYLD may be involved in the pathogenesis of synovial inflammation in RA as well as in the pro-inflammatory effects and hyperproliferation of RA-FLSs. CYLD may therefore provide a potential target for the treatment of RA. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene