About Enhancer

Enhancer ID: E_01_0674
Species: human
Position : chr9:134314290-134316290
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Maternal vitamin d osteoporosis
Pubmed ID:  30321476
Enhancer experiment: DNA methylation analysis,Quantitative DNA methylation analysis,RXRA methylation analysis,chemiluminescent assay,chemiluminescent assay,pyrosequencing
Enhancer experiment description: We therefore used an existing randomised trial to test the hypothesis that maternal gestational vitamin D supplementation would lead to reduced perinatal RXRA locus DNA methylation.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: We therefore used an existing randomised trial to test the hypothesis that maternal gestational vitamin D supplementation would lead to reduced perinatal RXRA locus DNA methylation.

About TF

TF name : RXRA(9530071D11Rik,Nr2b1,RXRalpha1)
TF experiment: DNA methylation analysis,Quantitative DNA methylation analysis,RXRA methylation analysis,chemiluminescent assay,chemiluminescent assay,pyrosequencing
TF experiment description: We therefore used an existing randomised trial to test the hypothesis that maternal gestational vitamin D supplementation would lead to reduced perinatal RXRA locus DNA methylation.

About Function

Enhancer function : We therefore used an existing randomised trial to test the hypothesis that maternal gestational vitamin D supplementation would lead to reduced perinatal RXRA locus DNA methylation.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 We therefore used an existing randomised trial to test the hypothesis that maternal gestational vitamin D supplementation would lead to reduced perinatal RXRA locus DNA methylation.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
RXRA a6b1 and a6b4 Integrin signaling pid 46
RXRA Activation of anterior HOX genes in hindbrain development during early embryogenesis reactome 120
RXRA Activation of gene expression by SREBF (SREBP) reactome 42
RXRA BMAL1:CLOCK,NPAS2 activates circadian gene expression reactome 42
RXRA Circadian Clock reactome 49
RXRA Endogenous sterols reactome 22
RXRA IL3 netpath 84
RXRA Import of palmitoyl-CoA into the mitochondrial matrix reactome 11
RXRA Nuclear Receptor transcription pathway reactome 51
RXRA PPARA activates gene expression reactome 113
RXRA Recycling of bile acids and salts reactome 15
RXRA Regulation of Androgen receptor activity pid 54
RXRA Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) reactome 20
RXRA Regulation of pyruvate dehydrogenase (PDH) complex reactome 14
RXRA Retinoic acid receptors-mediated signaling pid 30
RXRA RORA activates gene expression reactome 27
RXRA RXR and RAR heterodimerization with other nuclear receptor pid 26
RXRA Signaling by Retinoic Acid reactome 20
RXRA Synthesis of bile acids and bile salts reactome 7
RXRA Synthesis of bile acids and bile salts via 27-hydroxycholesterol reactome 15
RXRA Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol reactome 24
RXRA TNFalpha netpath 274
RXRA Transcriptional activation of mitochondrial biogenesis reactome 43
RXRA Transcriptional regulation of white adipocyte differentiation reactome 79
RXRA Vitamin D metabolism and pathway panther 6
RXRA YAP1- and WWTR1 (TAZ)-stimulated gene expression reactome 29
RXRA PPAR signaling pathway kegg 67
RXRA Adipocytokine signaling pathway kegg 65
RXRA Hepatitis C kegg 134
RXRA Pathways in cancer kegg 321
RXRA Thyroid cancer kegg 25
RXRA Small cell lung cancer kegg 83
RXRA Non-small cell lung cancer kegg 54

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs