About Enhancer
| Enhancer ID: | E_01_0673 |
| Species: | human |
| Position : | chr6:106042833-106044833   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | ?- thalassemia major |
| Pubmed ID: | 30324804 |
| Enhancer experiment: | quantitative real-time PCR?Flow cytometry and apoptosis assay?cell isolation and transduction |
| Enhancer experiment description: | Monitoring expression of ATG5, a key link between autophagy and apoptosis, we established that this correction correlates with reduction of enhanced autophagy activation, a typical feature of thalassemic polychromatophilic normoblasts. |
About Target gene
| Target gene : | ATG5 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Monitoring expression of ATG5, a key link between autophagy and apoptosis, we established that this correction correlates with reduction of enhanced autophagy activation, a typical feature of thalassemic polychromatophilic normoblasts. |
About TF
| TF name : | -- |
| TF experiment: | quantitative real-time PCR?Flow cytometry and apoptosis assay?cell isolation and transduction |
| TF experiment description: | Monitoring expression of ATG5, a key link between autophagy and apoptosis, we established that this correction correlates with reduction of enhanced autophagy activation, a typical feature of thalassemic polychromatophilic normoblasts. |
About Function
| Enhancer function : | Monitoring expression of ATG5, a key link between autophagy and apoptosis, we established that this correction correlates with reduction of enhanced autophagy activation, a typical feature of thalassemic polychromatophilic normoblasts. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Monitoring expression of ATG5, a key link between autophagy and apoptosis, we established that this correction correlates with reduction of enhanced autophagy activation, a typical feature of thalassemic polychromatophilic normoblasts. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene