About Enhancer
| Enhancer ID: | E_01_0671 |
| Species: | human |
| Position : | chr15:73991784-73993784   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Acute promyelocytic leukemia |
| Pubmed ID: | 30335887 |
| Enhancer experiment: | Chromatin immunoprecipitation? sequencing data analysis,Luciferase reporter gene assay,Retrovirus transfection,Reverse transcription?quantitative real?time PCR,ChIP?quantitative PCR |
| Enhancer experiment description: | Collectively, this study uncovers a novel mechanism of PML/RAR? mediated transcriptional activation and enriches our knowledge of the onco fusion protein mediated transcription activation. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Collectively, this study uncovers a novel mechanism of PML/RAR? mediated transcriptional activation and enriches our knowledge of the onco fusion protein mediated transcription activation. |
About TF
| TF name : | PML |
| TF experiment: | Chromatin immunoprecipitation? sequencing data analysis,Luciferase reporter gene assay,Retrovirus transfection,Reverse transcription?quantitative real?time PCR,ChIP?quantitative PCR |
| TF experiment description: | Collectively, this study uncovers a novel mechanism of PML/RAR? mediated transcriptional activation and enriches our knowledge of the onco fusion protein mediated transcription activation. |
About Function
| Enhancer function : | Collectively, this study uncovers a novel mechanism of PML/RAR? mediated transcriptional activation and enriches our knowledge of the onco fusion protein mediated transcription activation. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Collectively, this study uncovers a novel mechanism of PML/RAR? mediated transcriptional activation and enriches our knowledge of the onco fusion protein mediated transcription activation. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PML | C-MYC pathway | pid | 25 |
| PML | Direct p53 effectors | pid | 141 |
| PML | Interferon gamma signaling | reactome | 88 |
| PML | mTOR signaling pathway | pid | 66 |
| PML | p53 pathway | panther | 39 |
| PML | p73 transcription factor network | pid | 80 |
| PML | Regulation of TP53 Activity through Acetylation | reactome | 23 |
| PML | SUMOylation of DNA damage response and repair proteins | reactome | 76 |
| PML | TGF-beta receptor signaling | pid | 53 |
| PML | TGF_beta_Receptor | netpath | 220 |
| PML | TNFalpha | netpath | 274 |
| PML | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
| PML | Endocytosis | kegg | 201 |
| PML | Pathways in cancer | kegg | 321 |
| PML | Acute myeloid leukemia | kegg | 53 |
| PML | Hs_DNA_Damage_Response_WP707_82937 | wikipathways | 28 |
| PML | Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 | wikipathways | 28 |
| PML | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| PML | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene