About Enhancer
| Enhancer ID: | E_01_0660 |
| Species: | human |
| Position : | chr11:27652426-27654426   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Major depressive disorder (mdd) and chronic pain |
| Pubmed ID: | 30356873 |
| Enhancer experiment: | Quantitative RT-PCR,Open Field Test (OFT),Tail Suspension Test (TST),Forced Swimming Test (FST),Immunohistochemistry,Western Blot,Visceromotor Response (VMR) |
| Enhancer experiment description: | These results together suggest that DSS and CUS can induce the comorbidities of chronic pain and depression-like behavior. The pathology of this comorbidity involves loss of microglia within the mPFC with subsequent activation of NF-?B-p65 and down-regulation of BDNF/p-CREB signaling |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | These results together suggest that DSS and CUS can induce the comorbidities of chronic pain and depression-like behavior. The pathology of this comorbidity involves loss of microglia within the mPFC with subsequent activation of NF-?B-p65 and down-regulation of BDNF/p-CREB signaling |
About TF
| TF name : | BDNF |
| TF experiment: | Quantitative RT-PCR,Open Field Test (OFT),Tail Suspension Test (TST),Forced Swimming Test (FST),Immunohistochemistry,Western Blot,Visceromotor Response (VMR) |
| TF experiment description: | These results together suggest that DSS and CUS can induce the comorbidities of chronic pain and depression-like behavior. The pathology of this comorbidity involves loss of microglia within the mPFC with subsequent activation of NF-?B-p65 and down-regulation of BDNF/p-CREB signaling |
About Function
| Enhancer function : | These results together suggest that DSS and CUS can induce the comorbidities of chronic pain and depression-like behavior. The pathology of this comorbidity involves loss of microglia within the mPFC with subsequent activation of NF-?B-p65 and down-regulation of BDNF/p-CREB signaling |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
These results together suggest that DSS and CUS can induce the comorbidities of chronic pain and depression-like behavior. The pathology of this comorbidity involves loss of microglia within the mPFC with subsequent activation of NF-?B-p65 and down-regulation of BDNF/p-CREB signaling |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene