About Enhancer
| Enhancer ID: | E_01_0659 |
| Species: | human |
| Position : | chr1:6783119-6785119   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Amyotrophic lateral sclerosis and frontotemporal dementia |
| Pubmed ID: | 30357366 |
| Enhancer experiment: | TRAP immunoprecipitations,RNA extraction, qRT-PCR,Crosslink immunoprecipitation (CLIP),Immunostaining,Reporter transfection, dual luciferase assays, knockdown |
| Enhancer experiment description: | Our data reveal that TDP-43 can function as an mRNA-specific translational enhancer. Moreover, since CAMTA1 and DENND4A are linked to neurodegeneration, they suggest that this function could contribute to disease. |
About Target gene
| Target gene : | CAMTA1,DENND4A |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Our data reveal that TDP-43 can function as an mRNA-specific translational enhancer. Moreover, since CAMTA1 and DENND4A are linked to neurodegeneration, they suggest that this function could contribute to disease. ;Our data reveal that TDP-43 can function as an mRNA-specific translational enhancer. Moreover, since CAMTA1 and DENND4A are linked to neurodegeneration, they suggest that this function could contribute to disease. |
About TF
| TF name : | -- |
| TF experiment: | TRAP immunoprecipitations,RNA extraction, qRT-PCR,Crosslink immunoprecipitation (CLIP),Immunostaining,Reporter transfection, dual luciferase assays, knockdown |
| TF experiment description: | Our data reveal that TDP-43 can function as an mRNA-specific translational enhancer. Moreover, since CAMTA1 and DENND4A are linked to neurodegeneration, they suggest that this function could contribute to disease. ;Our data reveal that TDP-43 can function as an mRNA-specific translational enhancer. Moreover, since CAMTA1 and DENND4A are linked to neurodegeneration, they suggest that this function could contribute to disease. |
About Function
| Enhancer function : | Our data reveal that TDP-43 can function as an mRNA-specific translational enhancer. Moreover, since CAMTA1 and DENND4A are linked to neurodegeneration, they suggest that this function could contribute to disease. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Our data reveal that TDP-43 can function as an mRNA-specific translational enhancer. Moreover, since CAMTA1 and DENND4A are linked to neurodegeneration, they suggest that this function could contribute to disease. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene