About Enhancer
| Enhancer ID: | E_01_0657 |
| Species: | human |
| Position : | chr14:100235907-100237907   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Human papillomas |
| Pubmed ID: | 30359362 |
| Enhancer experiment: | ChIP,Chromatin immunoprecipitation,Western blot,RNA-Seq,FAIRE,qRT-PCR,3C |
| Enhancer experiment description: | Our data therefore reveal a key role for CTCF-YY1 dependent looping in the HPV life cycle and identify a regulatory mechanism that could be disrupted in HPV carcinogenesis. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Our data therefore reveal a key role for CTCF-YY1 dependent looping in the HPV life cycle and identify a regulatory mechanism that could be disrupted in HPV carcinogenesis. ;Our data therefore reveal a key role for CTCF-YY1 dependent looping in the HPV life cycle and identify a regulatory mechanism that could be disrupted in HPV carcinogenesis. |
About TF
| TF name : | YY1(DELTA,GADEVS,INO80S,NF-E1,UCRBP,YIN-YANG-1)CTCF(MRD21) |
| TF experiment: | ChIP,Chromatin immunoprecipitation,Western blot,RNA-Seq,FAIRE,qRT-PCR,3C |
| TF experiment description: | Our data therefore reveal a key role for CTCF-YY1 dependent looping in the HPV life cycle and identify a regulatory mechanism that could be disrupted in HPV carcinogenesis. ;Our data therefore reveal a key role for CTCF-YY1 dependent looping in the HPV life cycle and identify a regulatory mechanism that could be disrupted in HPV carcinogenesis. |
About Function
| Enhancer function : | Our data therefore reveal a key role for CTCF-YY1 dependent looping in the HPV life cycle and identify a regulatory mechanism that could be disrupted in HPV carcinogenesis. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Our data therefore reveal a key role for CTCF-YY1 dependent looping in the HPV life cycle and identify a regulatory mechanism that could be disrupted in HPV carcinogenesis. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| YY1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| YY1 | DNA Damage Recognition in GG-NER | reactome | 38 |
| YY1 | E2F transcription factor network | pid | 77 |
| YY1 | mTOR signaling pathway | pid | 66 |
| YY1 | Notch-mediated HES/HEY network | pid | 48 |
| YY1 | Notch | netpath | 76 |
| YY1 | Notch signaling pathway | pid | 58 |
| YY1 | p53 pathway | pid | 59 |
| YY1 | Signaling events mediated by HDAC Class I | pid | 89 |
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene