About Enhancer

Enhancer ID: E_01_0634
Species: human
Position : chr19:33297457-33299457
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Prostatic cancer
Pubmed ID:  30430607
Enhancer experiment: Immunohistochemistry,
Enhancer experiment description: Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers.;Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers.;Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers.;Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers.

About TF

TF name : CEBPA(C/EBP-alpha,CEBP)ERG(erg-3,p55)TMPRSS2PTEN
TF experiment: Immunohistochemistry,
TF experiment description: Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers.;Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers.;Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers.;Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers.

About Function

Enhancer function : Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
CEBPA AndrogenReceptor netpath 167
CEBPA C-MYB transcription factor network pid 87
CEBPA E2F transcription factor network pid 77
CEBPA EGFR1 netpath 475
CEBPA FOXA2 and FOXA3 transcription factor networks pid 45
CEBPA IL4 netpath 75
CEBPA Regulation of Androgen receptor activity pid 54
CEBPA Regulation of retinoblastoma protein pid 67
CEBPA Transcriptional regulation of white adipocyte differentiation reactome 79
CEBPA Validated targets of C-MYC transcriptional repression pid 63
CEBPA Pathways in cancer kegg 321
CEBPA Acute myeloid leukemia kegg 53
CEBPA Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 wikipathways 36
CEBPA Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 wikipathways 27
CEBPA Hs_Nucleotide_Metabolism_WP404_68960 wikipathways 16
CEBPA Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 wikipathways 9
ERG ERK cascade ( FGF8 signaling (Mouse) ) inoh 17
ERG ERK cascade ( FGF8 signaling (Xenopus) ) inoh 17
ERG FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) inoh 20
ERG FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) inoh 18
ERG PDGF signaling pathway panther 113
ERG Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
TMPRSS2 Coregulation of Androgen receptor activity pid 61
TMPRSS2 Regulation of Androgen receptor activity pid 54
PTEN 3-phosphoinositide degradation humancyc 20
PTEN AKT(PKB)-mTOR signaling ( Insulin receptor signaling (Mammal) ) inoh 15
PTEN AKT(PKB)-TOR signaling ( Insulin receptor signaling (D. melanogaster) ) inoh 15
PTEN AndrogenReceptor netpath 167
PTEN AP-1 transcription factor network pid 71
PTEN BCR signaling pathway pid 70
PTEN Class I PI3K signaling events pid 46
PTEN D-myo-inositol (1,3,4)-trisphosphate biosynthesis humancyc 15
PTEN Direct p53 effectors pid 141
PTEN Downstream TCR signaling reactome 101
PTEN EGFR1 netpath 475
PTEN Hypoxia response via HIF activation panther 16
PTEN Inflammation mediated by chemokine and cytokine signaling pathway panther 189
PTEN Inositol phosphate metabolism ( Inositol phosphate metabolism ) inoh 42
PTEN Insulin/IGF pathway-protein kinase B signaling cascade panther 22
PTEN Joubert syndrome smpdb 21
PTEN Leptin netpath 98
PTEN Negative regulation of the PI3K/AKT network reactome 8
PTEN p53 pathway panther 39
PTEN p53 pathway feedback loops 2 panther 42
PTEN PDGFR-beta signaling pathway pid 125
PTEN Phosphatidylinositol Phosphate Metabolism smpdb 21
PTEN PI3 kinase pathway panther 38
PTEN PIP3 activates AKT signaling reactome 81
PTEN RhoA signaling pathway pid 46
PTEN Signaling events mediated by Stem cell factor receptor (c-Kit) pid 53
PTEN superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism humancyc 20
PTEN superpathway of inositol phosphate compounds humancyc 68
PTEN Synthesis of IP3 and IP4 in the cytosol reactome 27
PTEN Synthesis of PIPs at the plasma membrane reactome 34
PTEN TCR signaling in nave CD4+ T cells pid 69
PTEN TP53 Regulates Metabolic Genes reactome 85
PTEN Inositol phosphate metabolism kegg 54
PTEN Phosphatidylinositol signaling system kegg 78
PTEN p53 signaling pathway kegg 66
PTEN Focal adhesion kegg 197
PTEN Tight junction kegg 131
PTEN Pathways in cancer kegg 321
PTEN Endometrial cancer kegg 52
PTEN Glioma kegg 65
PTEN Prostate cancer kegg 85
PTEN Melanoma kegg 69
PTEN Small cell lung cancer kegg 83
PTEN Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
PTEN Hs_Neural_Crest_Differentiation_WP2064_79263 wikipathways 40
PTEN Hs_Integrated_Cancer_Pathway_WP1971_82939 wikipathways 33

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs