About Enhancer
| Enhancer ID: | E_01_0632 |
| Species: | human |
| Position : | chr4:190171332-190173332   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Facioscapulohumeral muscular dystrophy |
| Pubmed ID: | 30446688 |
| Enhancer experiment: | Annexin V/7-AAD staining,Luciferase assay,RT-qPCR,immunostaining,western blots |
| Enhancer experiment description: | Anti-myogenic properties of DUX4 in human myogenic progenitor cells, and provide an example of enhancer disruption in the downregulation of MYF5. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Anti-myogenic properties of DUX4 in human myogenic progenitor cells, and provide an example of enhancer disruption in the downregulation of MYF5. ;Anti-myogenic properties of DUX4 in human myogenic progenitor cells, and provide an example of enhancer disruption in the downregulation of MYF5. |
About TF
| TF name : | DUX4L1MYF5 |
| TF experiment: | Annexin V/7-AAD staining,Luciferase assay,RT-qPCR,immunostaining,western blots |
| TF experiment description: | Anti-myogenic properties of DUX4 in human myogenic progenitor cells, and provide an example of enhancer disruption in the downregulation of MYF5. ;Anti-myogenic properties of DUX4 in human myogenic progenitor cells, and provide an example of enhancer disruption in the downregulation of MYF5. |
About Function
| Enhancer function : | Anti-myogenic properties of DUX4 in human myogenic progenitor cells, and provide an example of enhancer disruption in the downregulation of MYF5. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Anti-myogenic properties of DUX4 in human myogenic progenitor cells, and provide an example of enhancer disruption in the downregulation of MYF5. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYF5 | CDO in myogenesis | reactome | 29 |
| MYF5 | ID | netpath | 38 |
| MYF5 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene