About Enhancer
| Enhancer ID: | E_01_0628 |
| Species: | human |
| Position : | chr15:78562655-78564655   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Nicotine dependence and other smoking related disorders |
| Pubmed ID: | 30453884 |
| Enhancer experiment: | Logistic regression?Multivariate regression |
| Enhancer experiment description: | rs4887074 is associated with CHRNB4 expression, and along with two regulatory variants of CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk. |
About Target gene
| Target gene : | CHRNA5 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | rs4887074 is associated with CHRNB4 expression, and along with two regulatory variants of CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk. |
About TF
| TF name : | -- |
| TF experiment: | Logistic regression?Multivariate regression |
| TF experiment description: | rs4887074 is associated with CHRNB4 expression, and along with two regulatory variants of CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk. |
About Function
| Enhancer function : | rs4887074 is associated with CHRNB4 expression, and along with two regulatory variants of CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
rs4887074 is associated with CHRNB4 expression, and along with two regulatory variants of CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk. |
About SNP
| SNP ID: | rs16969968,rs880395,rs1948,rs4887074 |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene