About Enhancer
| Enhancer ID: | E_01_0620 |
| Species: | human |
| Position : | chr7:16788696-16790696   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Renal cell carcinoma |
| Pubmed ID: | 32593213 |
| Enhancer experiment: | Rtq-PCR,Western blot,Enzyme-linked immunosorbent assays,Statistical analysis |
| Enhancer experiment description: | Our data showed that AGR2 upregulated both HIF-1? and HIF-2? expression in Caki-1 cells increasing the expression of HIF-activated genes (glucose transporter 1, phosphoglycerate kinase 1, vascular endothelial growth factor A, and transforming growth factor-alpha) under the hypoxic conditions. |
About Target gene
| Target gene : | AGR2 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Our data showed that AGR2 upregulated both HIF-1? and HIF-2? expression in Caki-1 cells increasing the expression of HIF-activated genes (glucose transporter 1, phosphoglycerate kinase 1, vascular endothelial growth factor A, and transforming growth factor-alpha) under the hypoxic conditions. |
About TF
| TF name : | -- |
| TF experiment: | Rtq-PCR,Western blot,Enzyme-linked immunosorbent assays,Statistical analysis |
| TF experiment description: | Our data showed that AGR2 upregulated both HIF-1? and HIF-2? expression in Caki-1 cells increasing the expression of HIF-activated genes (glucose transporter 1, phosphoglycerate kinase 1, vascular endothelial growth factor A, and transforming growth factor-alpha) under the hypoxic conditions. |
About Function
| Enhancer function : | Our data showed that AGR2 upregulated both HIF-1? and HIF-2? expression in Caki-1 cells increasing the expression of HIF-activated genes (glucose transporter 1, phosphoglycerate kinase 1, vascular endothelial growth factor A, and transforming growth factor-alpha) under the hypoxic conditions. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Our data showed that AGR2 upregulated both HIF-1? and HIF-2? expression in Caki-1 cells increasing the expression of HIF-activated genes (glucose transporter 1, phosphoglycerate kinase 1, vascular endothelial growth factor A, and transforming growth factor-alpha) under the hypoxic conditions. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene