About Enhancer
| Enhancer ID: | E_01_0600 |
| Species: | human |
| Position : | chr1:173856174-173858174   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Inflammation |
| Pubmed ID: | 32467994 |
| Enhancer experiment: | RT?qPCR?Western blot?Flow cytometry |
| Enhancer experiment description: | The results showed that HG treatment induced ER stress in ARPE 19 human adult retinal pigment epithelial cells by upregulating the expression levels of phosphorylated (p) protein kinase R like ER kinase, p eukaryotic initiation factor 2?, activating transcription factor 4 and CCAAT/enhancer-binding protein homologous protein. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | The results showed that HG treatment induced ER stress in ARPE 19 human adult retinal pigment epithelial cells by upregulating the expression levels of phosphorylated (p) protein kinase R like ER kinase, p eukaryotic initiation factor 2?, activating transcription factor 4 and CCAAT/enhancer-binding protein homologous protein. |
About TF
| TF name : | GAS5 |
| TF experiment: | RT?qPCR?Western blot?Flow cytometry |
| TF experiment description: | The results showed that HG treatment induced ER stress in ARPE 19 human adult retinal pigment epithelial cells by upregulating the expression levels of phosphorylated (p) protein kinase R like ER kinase, p eukaryotic initiation factor 2?, activating transcription factor 4 and CCAAT/enhancer-binding protein homologous protein. |
About Function
| Enhancer function : | The results showed that HG treatment induced ER stress in ARPE 19 human adult retinal pigment epithelial cells by upregulating the expression levels of phosphorylated (p) protein kinase R like ER kinase, p eukaryotic initiation factor 2?, activating transcription factor 4 and CCAAT/enhancer-binding protein homologous protein. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
The results showed that HG treatment induced ER stress in ARPE 19 human adult retinal pigment epithelial cells by upregulating the expression levels of phosphorylated (p) protein kinase R like ER kinase, p eukaryotic initiation factor 2?, activating transcription factor 4 and CCAAT/enhancer-binding protein homologous protein. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene