About Enhancer
| Enhancer ID: |
E_01_0599 |
| Species: |
human |
| Position :
|
chr5:177083579-177085579
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Alveolar rhabdomyosarcomas |
| Pubmed ID: |
32464274
|
| Enhancer experiment: |
Real-Time RT-PCR quantification,ChIP-seq,Immunoblotting,Immunocytochemistry |
| Enhancer experiment description: |
These changes were associated with a significant reduction in FGFR4 transcript levels in treated cells. These decreases in H3K4me1 in the FGFR4 super enhancer were also associated with a 240-fold increase in KDM5B (JARID1B) mRNA levels. |
About Target gene
| Target gene : |
FGFR4 |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
These changes were associated with a significant reduction in FGFR4 transcript levels in treated cells. These decreases in H3K4me1 in the FGFR4 super enhancer were also associated with a 240-fold increase in KDM5B (JARID1B) mRNA levels. |
About TF
| TF name : |
-- |
| TF experiment: |
Real-Time RT-PCR quantification,ChIP-seq,Immunoblotting,Immunocytochemistry |
| TF experiment description: |
These changes were associated with a significant reduction in FGFR4 transcript levels in treated cells. These decreases in H3K4me1 in the FGFR4 super enhancer were also associated with a 240-fold increase in KDM5B (JARID1B) mRNA levels. |
About Function
| Enhancer function : |
These changes were associated with a significant reduction in FGFR4 transcript levels in treated cells. These decreases in H3K4me1 in the FGFR4 super enhancer were also associated with a 240-fold increase in KDM5B (JARID1B) mRNA levels. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
These changes were associated with a significant reduction in FGFR4 transcript levels in treated cells. These decreases in H3K4me1 in the FGFR4 super enhancer were also associated with a 240-fold increase in KDM5B (JARID1B) mRNA levels. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs