About Enhancer

Enhancer ID: E_01_0592
Species: human
Position : chr19:18371889-18373889
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Type 2 diabetes
Pubmed ID:  32427048
Enhancer experiment: ChIP-seq
Enhancer experiment description: Noncoding variation within a metformin-activated enhancer may increase GDF15 expression and help to predict GDF15 levels.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Noncoding variation within a metformin-activated enhancer may increase GDF15 expression and help to predict GDF15 levels.

About TF

TF name : GDF15
TF experiment: ChIP-seq
TF experiment description: Noncoding variation within a metformin-activated enhancer may increase GDF15 expression and help to predict GDF15 levels.

About Function

Enhancer function : Noncoding variation within a metformin-activated enhancer may increase GDF15 expression and help to predict GDF15 levels.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 Noncoding variation within a metformin-activated enhancer may increase GDF15 expression and help to predict GDF15 levels.

About SNP

SNP ID: rs888663,rs62122429,rs4808791

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
GDF15 Direct p53 effectors pid 141
GDF15 p73 transcription factor network pid 80
GDF15 TGF-beta signaling pathway panther 88
GDF15 Validated transcriptional targets of TAp63 isoforms pid 54

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs