About Enhancer
| Enhancer ID: | E_01_0590 |
| Species: | human |
| Position : | chr13:28000167-28002167   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Acute lymphoblastic leukemia |
| Pubmed ID: | 32384149 |
| Enhancer experiment: | RNA-seq |
| Enhancer experiment description: | Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among the most common driver events in acute leukemia, leading to increased cell proliferation and survival through activation of the PI3K/AKT, RAS/MAPK and STAT5 signaling pathways. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among the most common driver events in acute leukemia, leading to increased cell proliferation and survival through activation of the PI3K/AKT, RAS/MAPK and STAT5 signaling pathways. |
About TF
| TF name : | FLT3 |
| TF experiment: | RNA-seq |
| TF experiment description: | Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among the most common driver events in acute leukemia, leading to increased cell proliferation and survival through activation of the PI3K/AKT, RAS/MAPK and STAT5 signaling pathways. |
About Function
| Enhancer function : | Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among the most common driver events in acute leukemia, leading to increased cell proliferation and survival through activation of the PI3K/AKT, RAS/MAPK and STAT5 signaling pathways. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among the most common driver events in acute leukemia, leading to increased cell proliferation and survival through activation of the PI3K/AKT, RAS/MAPK and STAT5 signaling pathways. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FLT3 | Signaling by Interleukins | reactome | 47 |
| FLT3 | Cytokine-cytokine receptor interaction | kegg | 213 |
| FLT3 | Pathways in cancer | kegg | 321 |
| FLT3 | Acute myeloid leukemia | kegg | 53 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene