About Enhancer
| Enhancer ID: | E_01_0588 |
| Species: | human |
| Position : | chr12:57456839-57458839   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Multiple malignancies |
| Pubmed ID: | 32376693 |
| Enhancer experiment: | RNA-seq?ATAC-seq?RNA isolation?Immunoprecipations |
| Enhancer experiment description: | Here, we provide evidence that GLI1 controls chromatin accessibility at distal regulatory regions by modulating the recruitment of SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2 (SMARCA2) to these elements. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Here, we provide evidence that GLI1 controls chromatin accessibility at distal regulatory regions by modulating the recruitment of SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2 (SMARCA2) to these elements. |
About TF
| TF name : | GLI1(AV235269,Zfp-5,Zfp5) |
| TF experiment: | RNA-seq?ATAC-seq?RNA isolation?Immunoprecipations |
| TF experiment description: | Here, we provide evidence that GLI1 controls chromatin accessibility at distal regulatory regions by modulating the recruitment of SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2 (SMARCA2) to these elements. |
About Function
| Enhancer function : | Here, we provide evidence that GLI1 controls chromatin accessibility at distal regulatory regions by modulating the recruitment of SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2 (SMARCA2) to these elements. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Here, we provide evidence that GLI1 controls chromatin accessibility at distal regulatory regions by modulating the recruitment of SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2 (SMARCA2) to these elements. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GLI1 | Ci/Gli processing signaling ( Hedgehog signaling pathway ) | inoh | 17 |
| GLI1 | Degradation of GLI1 by the proteasome | reactome | 59 |
| GLI1 | FAS signaling pathway | panther | 37 |
| GLI1 | GLI proteins bind promoters of Hh responsive genes to promote transcription | reactome | 7 |
| GLI1 | Hedgehog 'off' state | reactome | 43 |
| GLI1 | Hedgehog 'on' state | reactome | 72 |
| GLI1 | Hedgehog | netpath | 39 |
| GLI1 | Hedgehog signaling events mediated by Gli proteins | pid | 49 |
| GLI1 | Hedgehog signaling pathway | panther | 19 |
| GLI1 | Signaling without Hh ( Hedgehog signaling pathway ) | inoh | 7 |
| GLI1 | Hedgehog signaling pathway | kegg | 53 |
| GLI1 | Pathways in cancer | kegg | 321 |
| GLI1 | Basal cell carcinoma | kegg | 51 |
| GLI1 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene