About Enhancer
| Enhancer ID: | E_01_0580 |
| Species: | human |
| Position : | chr1:161763935-161765935   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Ischemia |
| Pubmed ID: | 32340270 |
| Enhancer experiment: | Quantitative Real-Time PCR?Western Blot |
| Enhancer experiment description: | IR significantly increased reactive oxygen species (ROS) production and the percentage of apoptotic cells without the up-regulation of Nrf2, of the related antioxidant response element (ARE) gene expression or of the pro-survival UPR activating transcription factor 6 (ATF6) gene, whereas it significantly increased the pro-apoptotic CCAAT-enhancer-binding protein homologous protein (CHOP). |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | IR significantly increased reactive oxygen species (ROS) production and the percentage of apoptotic cells without the up-regulation of Nrf2, of the related antioxidant response element (ARE) gene expression or of the pro-survival UPR activating transcription factor 6 (ATF6) gene, whereas it significantly increased the pro-apoptotic CCAAT-enhancer-binding protein homologous protein (CHOP). |
About TF
| TF name : | ATF6 |
| TF experiment: | Quantitative Real-Time PCR?Western Blot |
| TF experiment description: | IR significantly increased reactive oxygen species (ROS) production and the percentage of apoptotic cells without the up-regulation of Nrf2, of the related antioxidant response element (ARE) gene expression or of the pro-survival UPR activating transcription factor 6 (ATF6) gene, whereas it significantly increased the pro-apoptotic CCAAT-enhancer-binding protein homologous protein (CHOP). |
About Function
| Enhancer function : | IR significantly increased reactive oxygen species (ROS) production and the percentage of apoptotic cells without the up-regulation of Nrf2, of the related antioxidant response element (ARE) gene expression or of the pro-survival UPR activating transcription factor 6 (ATF6) gene, whereas it significantly increased the pro-apoptotic CCAAT-enhancer-binding protein homologous protein (CHOP). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
IR significantly increased reactive oxygen species (ROS) production and the percentage of apoptotic cells without the up-regulation of Nrf2, of the related antioxidant response element (ARE) gene expression or of the pro-survival UPR activating transcription factor 6 (ATF6) gene, whereas it significantly increased the pro-apoptotic CCAAT-enhancer-binding protein homologous protein (CHOP). |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ATF6 | Apoptosis signaling pathway | panther | 104 |
| ATF6 | ATF4 activates genes | reactome | 25 |
| ATF6 | ATF6-alpha activates chaperone genes | reactome | 10 |
| ATF6 | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| ATF6 | Protein processing in endoplasmic reticulum | kegg | 166 |
| ATF6 | Alzheimer's disease | kegg | 167 |
| ATF6 | Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330 | wikipathways | 6 |
| ATF6 | Hs_Sterol_Regulatory_Element-Binding_Proteins_(SREBP)_signalling_WP1982_90425 | wikipathways | 15 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene