About Enhancer
| Enhancer ID: | E_01_0563 |
| Species: | human |
| Position : | chr17:72118099-72120099   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Triple-negative breast cancer |
| Pubmed ID: | 32398735 |
| Enhancer experiment: | Immunohistochemistry?RNA isolation?quantitative RT-PCR?Western Blot?ChIP-Seq?ChIP-PCR?Co-immunoprecipitation assays |
| Enhancer experiment description: | Mechanistically, SOX9 may sensitize TNBC cells to THZ1, in a FOXC1-related manner, suggesting that SOX9 could be as a predictive factor of THZ1. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Mechanistically, SOX9 may sensitize TNBC cells to THZ1, in a FOXC1-related manner, suggesting that SOX9 could be as a predictive factor of THZ1. |
About TF
| TF name : | SOX9(CMD1,CMPD1,SRA1,SRXX2,SRXY10) |
| TF experiment: | Immunohistochemistry?RNA isolation?quantitative RT-PCR?Western Blot?ChIP-Seq?ChIP-PCR?Co-immunoprecipitation assays |
| TF experiment description: | Mechanistically, SOX9 may sensitize TNBC cells to THZ1, in a FOXC1-related manner, suggesting that SOX9 could be as a predictive factor of THZ1. |
About Function
| Enhancer function : | Mechanistically, SOX9 may sensitize TNBC cells to THZ1, in a FOXC1-related manner, suggesting that SOX9 could be as a predictive factor of THZ1. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Mechanistically, SOX9 may sensitize TNBC cells to THZ1, in a FOXC1-related manner, suggesting that SOX9 could be as a predictive factor of THZ1. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SOX9 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| SOX9 | TGF_beta_Receptor | netpath | 220 |
| SOX9 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| SOX9 | Hs_Spinal_Cord_Injury_WP2431_87678 | wikipathways | 21 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene