About Enhancer
| Enhancer ID: | E_01_0558 |
| Species: | human |
| Position : | chrX:49247713-49249713   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Immune tolerance |
| Pubmed ID: | 32386462 |
| Enhancer experiment: | Flow cytometry?RT-PCR?Western blotting |
| Enhancer experiment description: | We show that the activity of the master transcription factor Forkhead-box protein 3 (FOXP3) attenuates p65 phosphorylation and nuclear translocation of the NF- B proteins p50, p65 and c-Rel following activation in human Treg. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | We show that the activity of the master transcription factor Forkhead-box protein 3 (FOXP3) attenuates p65 phosphorylation and nuclear translocation of the NF- B proteins p50, p65 and c-Rel following activation in human Treg. |
About TF
| TF name : | FOXP3 |
| TF experiment: | Flow cytometry?RT-PCR?Western blotting |
| TF experiment description: | We show that the activity of the master transcription factor Forkhead-box protein 3 (FOXP3) attenuates p65 phosphorylation and nuclear translocation of the NF- B proteins p50, p65 and c-Rel following activation in human Treg. |
About Function
| Enhancer function : | We show that the activity of the master transcription factor Forkhead-box protein 3 (FOXP3) attenuates p65 phosphorylation and nuclear translocation of the NF- B proteins p50, p65 and c-Rel following activation in human Treg. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
We show that the activity of the master transcription factor Forkhead-box protein 3 (FOXP3) attenuates p65 phosphorylation and nuclear translocation of the NF- B proteins p50, p65 and c-Rel following activation in human Treg. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXP3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| FOXP3 | IL2 signaling events mediated by STAT5 | pid | 30 |
| FOXP3 | Hs_Allograft_Rejection_WP2328_90020 | wikipathways | 12 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene