About Enhancer
| Enhancer ID: | E_01_0519 |
| Species: | human |
| Position : | chr1:56491946-56493946   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Calcific aortic valve disease (cavd) |
| Pubmed ID: | 29726894 |
| Enhancer experiment: | Real-time PCR,Western blot,Whole-genome gene expression,DNA methylation,Pyrosequencing,ChIP,Cell Transfection,Luciferase reporter assay,Determination of alkaline phosphatase activity, |
| Enhancer experiment description: | DNA methylation of a MIR-based enhancer downregulates the expression of PLPP3 and promotes the mineralization of the AV. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | DNA methylation of a MIR-based enhancer downregulates the expression of PLPP3 and promotes the mineralization of the AV. |
About TF
| TF name : | PLPP3 |
| TF experiment: | Real-time PCR,Western blot,Whole-genome gene expression,DNA methylation,Pyrosequencing,ChIP,Cell Transfection,Luciferase reporter assay,Determination of alkaline phosphatase activity, |
| TF experiment description: | DNA methylation of a MIR-based enhancer downregulates the expression of PLPP3 and promotes the mineralization of the AV. |
About Function
| Enhancer function : | DNA methylation of a MIR-based enhancer downregulates the expression of PLPP3 and promotes the mineralization of the AV. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
DNA methylation of a MIR-based enhancer downregulates the expression of PLPP3 and promotes the mineralization of the AV. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PLPP3 | Sphingolipid de novo biosynthesis | reactome | 36 |
| PLPP3 | triacylglycerol biosynthesis | humancyc | 27 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene