About Enhancer
| Enhancer ID: | E_01_0511 |
| Species: | human |
| Position : | chrX:44870832-44872832   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Acute myeloid leukemia |
| Pubmed ID: | 29736013 |
| Enhancer experiment: | PCR,qRTPCR,cDNA synthesis,Flow cytometry,Protein extraction,immunoblotting,coimmunoprecipitation,Proliferation assays,Plasmids,cloning,Histological analysis of mouse tissue,RNA extraction,RNA-seq,ChIPseq,ChIPqPCR,ATACseq,Chipseq,motif analysis,GSEA,data visualization,LCMS/MS analysis,Exome sequencing,Exome data analysis, |
| Enhancer experiment description: | Collectively, our findings identify a dual role for UTX in suppressing acute myeloid leukemia via repression of oncogenic ETS and upregulation of tumor-suppressive GATA programs. |
About Target gene
| Target gene : | KDM6A |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Collectively, our findings identify a dual role for UTX in suppressing acute myeloid leukemia via repression of oncogenic ETS and upregulation of tumor-suppressive GATA programs. |
About TF
| TF name : | -- |
| TF experiment: | PCR,qRTPCR,cDNA synthesis,Flow cytometry,Protein extraction,immunoblotting,coimmunoprecipitation,Proliferation assays,Plasmids,cloning,Histological analysis of mouse tissue,RNA extraction,RNA-seq,ChIPseq,ChIPqPCR,ATACseq,Chipseq,motif analysis,GSEA,data visualization,LCMS/MS analysis,Exome sequencing,Exome data analysis, |
| TF experiment description: | Collectively, our findings identify a dual role for UTX in suppressing acute myeloid leukemia via repression of oncogenic ETS and upregulation of tumor-suppressive GATA programs. |
About Function
| Enhancer function : | Collectively, our findings identify a dual role for UTX in suppressing acute myeloid leukemia via repression of oncogenic ETS and upregulation of tumor-suppressive GATA programs. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Collectively, our findings identify a dual role for UTX in suppressing acute myeloid leukemia via repression of oncogenic ETS and upregulation of tumor-suppressive GATA programs. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene