About Enhancer
| Enhancer ID: | E_01_0496 |
| Species: | human |
| Position : | chrY:2784042-2786042   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Mammary cancer |
| Pubmed ID: | 29749465 |
| Enhancer experiment: | CCID assay,Transfection,RT-qPCR,Western blot,immunofluorescence, |
| Enhancer experiment description: | In addition, the current findings indicate that there is crosstalk between SOX18 and nuclear factor ?-light-chain-enhancer of activated B cells, which was demonstrated to contribute to MDA-MB231/lymph endothelial intravasation. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to LEC retraction. |
About Target gene
| Target gene : | PROX1(PROX1) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | In addition, the current findings indicate that there is crosstalk between SOX18 and nuclear factor ?-light-chain-enhancer of activated B cells, which was demonstrated to contribute to MDA-MB231/lymph endothelial intravasation. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to LEC retraction.;In addition, the current findings indicate that there is crosstalk between SOX18 and nuclear factor ?-light-chain-enhancer of activated B cells, which was demonstrated to contribute to MDA-MB231/lymph endothelial intravasation. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to LEC retraction.;In addition, the current findings indicate that there is crosstalk between SOX18 and nuclear factor ?-light-chain-enhancer of activated B cells, which was demonstrated to contribute to MDA-MB231/lymph endothelial intravasation. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to LEC retraction. |
About TF
| TF name : | SRY(Tdf,Tdy)SOX18 |
| TF experiment: | CCID assay,Transfection,RT-qPCR,Western blot,immunofluorescence, |
| TF experiment description: | In addition, the current findings indicate that there is crosstalk between SOX18 and nuclear factor ?-light-chain-enhancer of activated B cells, which was demonstrated to contribute to MDA-MB231/lymph endothelial intravasation. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to LEC retraction.;In addition, the current findings indicate that there is crosstalk between SOX18 and nuclear factor ?-light-chain-enhancer of activated B cells, which was demonstrated to contribute to MDA-MB231/lymph endothelial intravasation. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to LEC retraction.;In addition, the current findings indicate that there is crosstalk between SOX18 and nuclear factor ?-light-chain-enhancer of activated B cells, which was demonstrated to contribute to MDA-MB231/lymph endothelial intravasation. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to LEC retraction. |
About Function
| Enhancer function : | In addition, the current findings indicate that there is crosstalk between SOX18 and nuclear factor ?-light-chain-enhancer of activated B cells, which was demonstrated to contribute to MDA-MB231/lymph endothelial intravasation. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to LEC retraction. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
In addition, the current findings indicate that there is crosstalk between SOX18 and nuclear factor ?-light-chain-enhancer of activated B cells, which was demonstrated to contribute to MDA-MB231/lymph endothelial intravasation. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to LEC retraction. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SRY | AndrogenReceptor | netpath | 167 |
| SRY | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| SRY | Regulation of Androgen receptor activity | pid | 54 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene