About Enhancer

Enhancer ID: E_01_0448
Species: human
Position : chr20:50188232-50190232
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Triple negative breast cancer (tnbc)
Pubmed ID:  29805099
Enhancer experiment: Short Pairpin RNAs (shRNA),Small Interfering RNA (siRNA),Genetic Knockout,Western Blot,RNA Extraction,Reverse Transcription,Real-Time Polymerase Chain Reaction,Flow Cytometry Analysis (FACS),Immunofluorescence Staining,Metabolic Assay,Bioinformatics Analysis
Enhancer experiment description: Collectively, tumor glycolysis orchestrates a molecular network of the AMPK-ULK1, autophagy, and CEBPB pathways to affect MDSCs and maintain tumor immunosuppression.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Collectively, tumor glycolysis orchestrates a molecular network of the AMPK-ULK1, autophagy, and CEBPB pathways to affect MDSCs and maintain tumor immunosuppression.

About TF

TF name : CEBPB(C/EBP-beta,IL6DBP,NF-IL6,TCF5)
TF experiment: Short Pairpin RNAs (shRNA),Small Interfering RNA (siRNA),Genetic Knockout,Western Blot,RNA Extraction,Reverse Transcription,Real-Time Polymerase Chain Reaction,Flow Cytometry Analysis (FACS),Immunofluorescence Staining,Metabolic Assay,Bioinformatics Analysis
TF experiment description: Collectively, tumor glycolysis orchestrates a molecular network of the AMPK-ULK1, autophagy, and CEBPB pathways to affect MDSCs and maintain tumor immunosuppression.

About Function

Enhancer function : Collectively, tumor glycolysis orchestrates a molecular network of the AMPK-ULK1, autophagy, and CEBPB pathways to affect MDSCs and maintain tumor immunosuppression.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 Collectively, tumor glycolysis orchestrates a molecular network of the AMPK-ULK1, autophagy, and CEBPB pathways to affect MDSCs and maintain tumor immunosuppression.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
CEBPB C-MYB transcription factor network pid 87
CEBPB EGFR1 netpath 475
CEBPB FOXA1 transcription factor network pid 45
CEBPB FOXA2 and FOXA3 transcription factor networks pid 45
CEBPB IFN-gamma pathway pid 43
CEBPB IL3-mediated signaling events pid 27
CEBPB IL4-mediated signaling events pid 66
CEBPB IL4 netpath 75
CEBPB IL6-mediated signaling events pid 48
CEBPB IL6 netpath 85
CEBPB RANKL netpath 84
CEBPB Regulation of nuclear SMAD2/3 signaling pid 82
CEBPB Regulation of retinoblastoma protein pid 67
CEBPB Senescence-Associated Secretory Phenotype (SASP) reactome 108
CEBPB Signaling mediated by p38-alpha and p38-beta pid 35
CEBPB TCR netpath 261
CEBPB Transcriptional regulation of white adipocyte differentiation reactome 79
CEBPB Validated nuclear estrogen receptor alpha network pid 65
CEBPB Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193 wikipathways 62
CEBPB Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44
CEBPB Hs_Transcriptional_activation_by_NRF2_WP3_79527 wikipathways 6
CEBPB Hs_Lung_fibrosis_WP3624_91475 wikipathways 23
CEBPB Hs_IL17_signaling_pathway_WP2112_89838 wikipathways 20

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs