About Enhancer
| Enhancer ID: | E_01_0415 |
| Species: | human |
| Position : | chr2:136111792-136113792   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Aids |
| Pubmed ID: | 29894816 |
| Enhancer experiment: | competitive binding assay,MTT assay,luciferase activity |
| Enhancer experiment description: | The current results indicate that 4DV3 might serve as a prototype for a new type of dual function ligand, one that acts as a HIV-1 entry inhibitor and a CXCR4 drug delivery targeting ligand. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | The current results indicate that 4DV3 might serve as a prototype for a new type of dual function ligand, one that acts as a HIV-1 entry inhibitor and a CXCR4 drug delivery targeting ligand. |
About TF
| TF name : | CXCR4 |
| TF experiment: | competitive binding assay,MTT assay,luciferase activity |
| TF experiment description: | The current results indicate that 4DV3 might serve as a prototype for a new type of dual function ligand, one that acts as a HIV-1 entry inhibitor and a CXCR4 drug delivery targeting ligand. |
About Function
| Enhancer function : | The current results indicate that 4DV3 might serve as a prototype for a new type of dual function ligand, one that acts as a HIV-1 entry inhibitor and a CXCR4 drug delivery targeting ligand. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
The current results indicate that 4DV3 might serve as a prototype for a new type of dual function ligand, one that acts as a HIV-1 entry inhibitor and a CXCR4 drug delivery targeting ligand. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CXCR4 | Axon guidance mediated by Slit/Robo | panther | 18 |
| CXCR4 | Chemokine receptors bind chemokines | reactome | 57 |
| CXCR4 | CXCR4-mediated signaling events | pid | 87 |
| CXCR4 | G alpha (i) signalling events | reactome | 241 |
| CXCR4 | HIF-1-alpha transcription factor network | pid | 67 |
| CXCR4 | IL4 | netpath | 75 |
| CXCR4 | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| CXCR4 | S1P3 pathway | pid | 25 |
| CXCR4 | Syndecan-4-mediated signaling events | pid | 32 |
| CXCR4 | Cytokine-cytokine receptor interaction | kegg | 213 |
| CXCR4 | Chemokine signaling pathway | kegg | 187 |
| CXCR4 | Endocytosis | kegg | 201 |
| CXCR4 | Axon guidance | kegg | 126 |
| CXCR4 | Leukocyte transendothelial migration | kegg | 116 |
| CXCR4 | Intestinal immune network for IgA production | kegg | 48 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene