About Enhancer
| Enhancer ID: | E_01_0360 |
| Species: | human |
| Position : | chr17:40306219-40308219   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Type 2 diabetes |
| Pubmed ID: | 30910956 |
| Enhancer experiment: | ChIP-Seq |
| Enhancer experiment description: | Among them, rs10772119 and rs883868 disrupt the binding of retinoic acid receptor ? (RARA) and Yin and Yang 1 (YY1), respectively. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Among them, rs10772119 and rs883868 disrupt the binding of retinoic acid receptor ? (RARA) and Yin and Yang 1 (YY1), respectively.;Among them, rs10772119 and rs883868 disrupt the binding of retinoic acid receptor ? (RARA) and Yin and Yang 1 (YY1), respectively. |
About TF
| TF name : | RARA(Nr1b1,RAR,RARalpha1)YY1(DELTA,GADEVS,INO80S,NF-E1,UCRBP,YIN-YANG-1) |
| TF experiment: | ChIP-Seq |
| TF experiment description: | Among them, rs10772119 and rs883868 disrupt the binding of retinoic acid receptor ? (RARA) and Yin and Yang 1 (YY1), respectively.;Among them, rs10772119 and rs883868 disrupt the binding of retinoic acid receptor ? (RARA) and Yin and Yang 1 (YY1), respectively. |
About Function
| Enhancer function : | Among them, rs10772119 and rs883868 disrupt the binding of retinoic acid receptor ? (RARA) and Yin and Yang 1 (YY1), respectively. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Among them, rs10772119 and rs883868 disrupt the binding of retinoic acid receptor ? (RARA) and Yin and Yang 1 (YY1), respectively. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RARA | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| RARA | FSH | netpath | 44 |
| RARA | IL3 | netpath | 84 |
| RARA | Nuclear Receptor transcription pathway | reactome | 51 |
| RARA | Retinoic acid receptors-mediated signaling | pid | 30 |
| RARA | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| RARA | Signaling by Retinoic Acid | reactome | 20 |
| RARA | Pathways in cancer | kegg | 321 |
| RARA | Acute myeloid leukemia | kegg | 53 |
| RARA | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 |
| YY1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| YY1 | DNA Damage Recognition in GG-NER | reactome | 38 |
| YY1 | E2F transcription factor network | pid | 77 |
| YY1 | mTOR signaling pathway | pid | 66 |
| YY1 | Notch-mediated HES/HEY network | pid | 48 |
| YY1 | Notch | netpath | 76 |
| YY1 | Notch signaling pathway | pid | 58 |
| YY1 | p53 pathway | pid | 59 |
| YY1 | Signaling events mediated by HDAC Class I | pid | 89 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene