About Enhancer
| Enhancer ID: | E_01_0315 |
| Species: | human |
| Position : | chr16:85896547-85898547   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 30657937 |
| Enhancer experiment: | HT nextPBM |
| Enhancer experiment description: | We analyze binding of PU.1/SPI1 and IRF8 from human monocytes, delineate DNA-sequence determinants for their cooperativity |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | We analyze binding of PU.1/SPI1 and IRF8 from human monocytes, delineate DNA-sequence determinants for their cooperativity |
About TF
| TF name : | IRF8(H-ICSBP,ICSBP,ICSBP1,IMD32A,IMD32B,IRF-8) |
| TF experiment: | HT nextPBM |
| TF experiment description: | We analyze binding of PU.1/SPI1 and IRF8 from human monocytes, delineate DNA-sequence determinants for their cooperativity |
About Function
| Enhancer function : | We analyze binding of PU.1/SPI1 and IRF8 from human monocytes, delineate DNA-sequence determinants for their cooperativity |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
We analyze binding of PU.1/SPI1 and IRF8 from human monocytes, delineate DNA-sequence determinants for their cooperativity |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| IRF8 | GMCSF-mediated signaling events | pid | 38 |
| IRF8 | Interferon alpha/beta signaling | reactome | 67 |
| IRF8 | Interferon gamma signaling | reactome | 88 |
| IRF8 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| IRF8 | Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 | wikipathways | 10 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene