About Enhancer
| Enhancer ID: | E_01_0311 |
| Species: | human |
| Position : | chr11:102517572-102519572   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Osteosarcoma |
| Pubmed ID: | 30662285 |
| Enhancer experiment: | Lentiviral transfection, gene knockdown, PCR, Western blot |
| Enhancer experiment description: | Notch3 may affect the invasiveness and metastasis of osteosarcoma cells by regulating the downstream target gene Hes1 and its effector protein, MMP7. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Notch3 may affect the invasiveness and metastasis of osteosarcoma cells by regulating the downstream target gene Hes1 and its effector protein, MMP7. |
About TF
| TF name : | MMP7 |
| TF experiment: | ???????????PCR?Western blot |
| TF experiment description: | Notch3 may affect the invasiveness and metastasis of osteosarcoma cells by regulating the downstream target gene Hes1 and its effector protein, MMP7. |
About Function
| Enhancer function : | Notch3 may affect the invasiveness and metastasis of osteosarcoma cells by regulating the downstream target gene Hes1 and its effector protein, MMP7. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Notch3 may affect the invasiveness and metastasis of osteosarcoma cells by regulating the downstream target gene Hes1 and its effector protein, MMP7. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MMP7 | Activation of Matrix Metalloproteinases | reactome | 32 |
| MMP7 | Alzheimer disease-presenilin pathway | panther | 98 |
| MMP7 | Assembly of collagen fibrils and other multimeric structures | reactome | 44 |
| MMP7 | Collagen degradation | reactome | 39 |
| MMP7 | Degradation of the extracellular matrix | reactome | 72 |
| MMP7 | p75(NTR)-mediated signaling | pid | 74 |
| MMP7 | Posttranslational regulation of adherens junction stability and dissassembly | pid | 50 |
| MMP7 | Syndecan-1-mediated signaling events | pid | 42 |
| MMP7 | Wnt signaling pathway | kegg | 135 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene