About Enhancer
| Enhancer ID: | E_01_0303 |
| Species: | human |
| Position : | chr7:128935299-128937299   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Type 1 diabetes |
| Pubmed ID: | 34529725 |
| Enhancer experiment: | Gel electrophoresis Western blot flow cytometry chip |
| Enhancer experiment description: | Here, we performed a comprehensive integrated post-GWAS analysis of T1D to identify functional regulatory variants in enhancers and their cognate target genes. Starting with 1,817 candidate T1D SNPs defined from the GWAS catalog and LDlink databases |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Here, we performed a comprehensive integrated post-GWAS analysis of T1D to identify functional regulatory variants in enhancers and their cognate target genes. Starting with 1,817 candidate T1D SNPs defined from the GWAS catalog and LDlink databases |
About TF
| TF name : | IRF5 |
| TF experiment: | ???? Western blot ????? CHIP |
| TF experiment description: | Here, we performed a comprehensive integrated post-GWAS analysis of T1D to identify functional regulatory variants in enhancers and their cognate target genes. Starting with 1,817 candidate T1D SNPs defined from the GWAS catalog and LDlink databases |
About Function
| Enhancer function : | Here, we performed a comprehensive integrated post-GWAS analysis of T1D to identify functional regulatory variants in enhancers and their cognate target genes. Starting with 1,817 candidate T1D SNPs defined from the GWAS catalog and LDlink databases |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Here, we performed a comprehensive integrated post-GWAS analysis of T1D to identify functional regulatory variants in enhancers and their cognate target genes. Starting with 1,817 candidate T1D SNPs defined from the GWAS catalog and LDlink databases |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| IRF5 | Direct p53 effectors | pid | 141 |
| IRF5 | Interferon alpha/beta signaling | reactome | 67 |
| IRF5 | Interferon gamma signaling | reactome | 88 |
| IRF5 | Toll-like receptor signaling pathway | kegg | 100 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene