About Enhancer

Enhancer ID: E_01_0265
Species: human
Position : chr19:29809345-29811345
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Gastric cancer
Pubmed ID:  31542774
Enhancer experiment: PCR,Flow cytometry
Enhancer experiment description: By integrating SVs associated with acetylated chro_x0002_matin identified by paired-end NanoChIP-seq (PeNChIP-seq) with whole-genome sequencing (WGS) analysis of a large GC cohort, we observed enhancer hijacking events in GC targeting CCNE1, IGF2 and CCND1.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: By integrating SVs associated with acetylated chro_x0002_matin identified by paired-end NanoChIP-seq (PeNChIP-seq) with whole-genome sequencing (WGS) analysis of a large GC cohort, we observed enhancer hijacking events in GC targeting CCNE1, IGF2 and CCND1.

About TF

TF name : CCNE1
TF experiment: PCR,Flow cytometry
TF experiment description: By integrating SVs associated with acetylated chro_x0002_matin identified by paired-end NanoChIP-seq (PeNChIP-seq) with whole-genome sequencing (WGS) analysis of a large GC cohort, we observed enhancer hijacking events in GC targeting CCNE1, IGF2 and CCND1.

About Function

Enhancer function : By integrating SVs associated with acetylated chro_x0002_matin identified by paired-end NanoChIP-seq (PeNChIP-seq) with whole-genome sequencing (WGS) analysis of a large GC cohort, we observed enhancer hijacking events in GC targeting CCNE1, IGF2 and CCND1.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 By integrating SVs associated with acetylated chro_x0002_matin identified by paired-end NanoChIP-seq (PeNChIP-seq) with whole-genome sequencing (WGS) analysis of a large GC cohort, we observed enhancer hijacking events in GC targeting CCNE1, IGF2 and CCND1.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
CCNE1 AndrogenReceptor netpath 167
CCNE1 Association of TriC/CCT with target proteins during biosynthesis reactome 39
CCNE1 BARD1 signaling events pid 29
CCNE1 BCR netpath 161
CCNE1 Cell cycle panther 14
CCNE1 Cyclin E associated events during G1/S transition reactome 14
CCNE1 DNA Damage/Telomere Stress Induced Senescence reactome 64
CCNE1 E2F mediated regulation of DNA replication reactome 17
CCNE1 E2F transcription factor network pid 77
CCNE1 FOXM1 transcription factor network pid 43
CCNE1 G0 and Early G1 reactome 25
CCNE1 G1/S-Specific Transcription reactome 17
CCNE1 IL2 netpath 81
CCNE1 mTOR signaling pathway pid 66
CCNE1 p53-Dependent G1 DNA Damage Response reactome 7
CCNE1 p53 pathway panther 39
CCNE1 p53 pathway feedback loops 2 panther 42
CCNE1 p73 transcription factor network pid 80
CCNE1 Parkinson disease panther 85
CCNE1 PLK3 signaling events pid 6
CCNE1 PTK6 Regulates Cell Cycle reactome 6
CCNE1 Regulation of retinoblastoma protein pid 67
CCNE1 SCF(Skp2)-mediated degradation of p27/p21 reactome 59
CCNE1 Signaling events mediated by PRL pid 23
CCNE1 TGF_beta_Receptor netpath 220
CCNE1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest reactome 13
CCNE1 TSH netpath 82
CCNE1 Cell cycle kegg 124
CCNE1 Oocyte meiosis kegg 110
CCNE1 p53 signaling pathway kegg 66
CCNE1 Pathways in cancer kegg 321
CCNE1 Prostate cancer kegg 85
CCNE1 Small cell lung cancer kegg 83
CCNE1 Hs_miRNAs_involved_in_DNA_damage_response_WP1545_84697 wikipathways 30
CCNE1 Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 wikipathways 28
CCNE1 Hs_MAPK_Signaling_Pathway_WP382_79951 wikipathways 58
CCNE1 Hs_Parkin-Ubiquitin_Proteasomal_System_pathway_WP2359_72121 wikipathways 17
CCNE1 Hs_White_fat_cell_differentiation_WP3946_90940 wikipathways 30
CCNE1 Hs_ID_signaling_pathway_WP53_67360 wikipathways 8

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs