About Enhancer
| Enhancer ID: | E_01_0253 |
| Species: | human |
| Position : | chr3:186840138-186842138   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 31563853 |
| Enhancer experiment: | Western blot, flow cytometry, PCR, immunofluorescence staining |
| Enhancer experiment description: | Relative to untreated control cells, T-brites had increased mRNA expression of PPAR? target genes (ADIPOQ, FABP3, FABP4, and RXRA) and brite/beige marker genes (PGC1?/?, PRDM16, CEBP?, CIDEA, and ELOVL3), without expression changes in lipogenic genes (FASN and SCD1) (Figure S4a and S4b) |
About Target gene
| Target gene : | ADIPOQ(30kDa,APN,Acdc,Acrp30,Ad,Adid,GBP28,adipo,apM1) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Relative to untreated control cells, T-brites had increased mRNA expression of PPAR? target genes (ADIPOQ, FABP3, FABP4, and RXRA) and brite/beige marker genes (PGC1?/?, PRDM16, CEBP?, CIDEA, and ELOVL3), without expression changes in lipogenic genes (FASN and SCD1) (Figure S4a and S4b) |
About TF
| TF name : | -- |
| TF experiment: | Western blot,Flow cytometry,PCR,?????? |
| TF experiment description: | Relative to untreated control cells, T-brites had increased mRNA expression of PPAR? target genes (ADIPOQ, FABP3, FABP4, and RXRA) and brite/beige marker genes (PGC1?/?, PRDM16, CEBP?, CIDEA, and ELOVL3), without expression changes in lipogenic genes (FASN and SCD1) (Figure S4a and S4b) |
About Function
| Enhancer function : | Relative to untreated control cells, T-brites had increased mRNA expression of PPAR? target genes (ADIPOQ, FABP3, FABP4, and RXRA) and brite/beige marker genes (PGC1?/?, PRDM16, CEBP?, CIDEA, and ELOVL3), without expression changes in lipogenic genes (FASN and SCD1) (Figure S4a and S4b) |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Relative to untreated control cells, T-brites had increased mRNA expression of PPAR? target genes (ADIPOQ, FABP3, FABP4, and RXRA) and brite/beige marker genes (PGC1?/?, PRDM16, CEBP?, CIDEA, and ELOVL3), without expression changes in lipogenic genes (FASN and SCD1) (Figure S4a and S4b) |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene