About Enhancer
| Enhancer ID: | E_01_0240 |
| Species: | human |
| Position : | chr3:194133931-194135931   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Acute lymphoblastic leukemia |
| Pubmed ID: | 31586130 |
| Enhancer experiment: | PCR,Western blot |
| Enhancer experiment description: | Furthermore, NRARP overexpression blocked NOTCH transcriptional activity as shown by the overall decreased expression of NOTCH1 downstream tar_x0002_gets HES1 and DTX1 in NRARP-overexpressing cells (Fig. 1f). |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Furthermore, NRARP overexpression blocked NOTCH transcriptional activity as shown by the overall decreased expression of NOTCH1 downstream tar_x0002_gets HES1 and DTX1 in NRARP-overexpressing cells (Fig. 1f). |
About TF
| TF name : | HES1 |
| TF experiment: | PCR,Western blot |
| TF experiment description: | Furthermore, NRARP overexpression blocked NOTCH transcriptional activity as shown by the overall decreased expression of NOTCH1 downstream tar_x0002_gets HES1 and DTX1 in NRARP-overexpressing cells (Fig. 1f). |
About Function
| Enhancer function : | Furthermore, NRARP overexpression blocked NOTCH transcriptional activity as shown by the overall decreased expression of NOTCH1 downstream tar_x0002_gets HES1 and DTX1 in NRARP-overexpressing cells (Fig. 1f). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Furthermore, NRARP overexpression blocked NOTCH transcriptional activity as shown by the overall decreased expression of NOTCH1 downstream tar_x0002_gets HES1 and DTX1 in NRARP-overexpressing cells (Fig. 1f). |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HES1 | ATF-2 transcription factor network | pid | 59 |
| HES1 | C-MYB transcription factor network | pid | 87 |
| HES1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | reactome | 57 |
| HES1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | reactome | 57 |
| HES1 | Fanconi anemia pathway | pid | 48 |
| HES1 | ID | netpath | 38 |
| HES1 | Notch-mediated HES/HEY network | pid | 48 |
| HES1 | Notch | netpath | 76 |
| HES1 | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| HES1 | NOTCH2 intracellular domain regulates transcription | reactome | 12 |
| HES1 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | reactome | 7 |
| HES1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| HES1 | Notch signaling pathway | kegg | 44 |
| HES1 | Maturity onset diabetes of the young | kegg | 25 |
| HES1 | Hs_Gene_regulatory_network_modelling_somitogenesis_WP2854_87527 | wikipathways | 12 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene