About Enhancer
| Enhancer ID: | E_01_0209 |
| Species: | human |
| Position : | chr4:110614447-110616447   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Atrial fibrillation |
| Pubmed ID: | 31636200 |
| Enhancer experiment: | Flow cytometry,PCR,Western blot |
| Enhancer experiment description: | Genome-wide association studies found that increased risk for atrial fibrillation (AF), the most common human heart arrhythmia,is associated with noncoding sequence variants located in proxim_x0002_ity to PITX2. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Genome-wide association studies found that increased risk for atrial fibrillation (AF), the most common human heart arrhythmia,is associated with noncoding sequence variants located in proxim_x0002_ity to PITX2. |
About TF
| TF name : | PITX2(9430085M16Rik,Brx1,Brx1b,Munc30,Otlx2,Ptx2,Rieg) |
| TF experiment: | Flow cytometry,PCR,Western blot |
| TF experiment description: | Genome-wide association studies found that increased risk for atrial fibrillation (AF), the most common human heart arrhythmia,is associated with noncoding sequence variants located in proxim_x0002_ity to PITX2. |
About Function
| Enhancer function : | Genome-wide association studies found that increased risk for atrial fibrillation (AF), the most common human heart arrhythmia,is associated with noncoding sequence variants located in proxim_x0002_ity to PITX2. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Genome-wide association studies found that increased risk for atrial fibrillation (AF), the most common human heart arrhythmia,is associated with noncoding sequence variants located in proxim_x0002_ity to PITX2. |
About SNP
| SNP ID: | rs2595104 |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PITX2 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| PITX2 | TGF-beta signaling pathway | kegg | 82 |
| PITX2 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| PITX2 | Hs_BMP_Signaling_Pathway_in_Eyelid_Development_WP3927_90735 | wikipathways | 11 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene