About Enhancer
| Enhancer ID: | E_01_0204 |
| Species: | human |
| Position : | chr4:184382613-184384613   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Colon cancer |
| Pubmed ID: | 31642979 |
| Enhancer experiment: | PCR,Flow cytometry |
| Enhancer experiment description: | Similarly, IRF2 was predicted to bind to the sequence with the T allele at rs7071351 (Fig. 3d) and IRF2 ChIP-seq peak was also found in the SNP region (Fig. 3b). |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Similarly, IRF2 was predicted to bind to the sequence with the T allele at rs7071351 (Fig. 3d) and IRF2 ChIP-seq peak was also found in the SNP region (Fig. 3b).;However, ZMIZ1-AS1 is a miscellaneous RNA gene with unknown function and both ZMIZ1 and ZMIZ1-AS1 failed to afect cell growth in our functionalinterrogation. |
About TF
| TF name : | IRF2ZMIZ1 |
| TF experiment: | PCR,Flow cytometry |
| TF experiment description: | Similarly, IRF2 was predicted to bind to the sequence with the T allele at rs7071351 (Fig. 3d) and IRF2 ChIP-seq peak was also found in the SNP region (Fig. 3b).;However, ZMIZ1-AS1 is a miscellaneous RNA gene with unknown function and both ZMIZ1 and ZMIZ1-AS1 failed to afect cell growth in our functionalinterrogation. |
About Function
| Enhancer function : | Similarly, IRF2 was predicted to bind to the sequence with the T allele at rs7071351 (Fig. 3d) and IRF2 ChIP-seq peak was also found in the SNP region (Fig. 3b). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Similarly, IRF2 was predicted to bind to the sequence with the T allele at rs7071351 (Fig. 3d) and IRF2 ChIP-seq peak was also found in the SNP region (Fig. 3b). |
About SNP
| SNP ID: | rs7071351 |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| IRF2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| IRF2 | Interferon alpha/beta signaling | reactome | 67 |
| IRF2 | Interferon gamma signaling | reactome | 88 |
| IRF2 | TRAF6 mediated IRF7 activation | reactome | 33 |
| IRF2 | Hs_Inflammatory_Response_Pathway_WP453_80206 | wikipathways | 6 |
| IRF2 | Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 | wikipathways | 10 |
| ZMIZ1 | AndrogenReceptor | netpath | 167 |
| ZMIZ1 | Coregulation of Androgen receptor activity | pid | 61 |
| ZMIZ1 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene