About Enhancer

Enhancer ID: E_01_0144
Species: human
Position : chr12:55740444-55742444
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Psoriasiform skin inflammation
Pubmed ID:  29563767
Enhancer experiment: miRNA transfection?Real-Time PCR,Western Blot,Immunofluorescence,ELISA Assays
Enhancer experiment description: Additionally, the activation of nuclear NF-?B (nuclear factor ?-light-chainenhancer of activated B cells) signaling pathway was repressed by GDF11 treatment. Collectively, GDF11 may represent a promising molecular target for the prevention and treatment of psoriasis-like skin inflammation.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Additionally, the activation of nuclear NF-?B (nuclear factor ?-light-chainenhancer of activated B cells) signaling pathway was repressed by GDF11 treatment. Collectively, GDF11 may represent a promising molecular target for the prevention and treatment of psoriasis-like skin inflammation.

About TF

TF name : GDF11
TF experiment: miRNA transfection?Real-Time PCR,Western Blot,Immunofluorescence,ELISA Assays
TF experiment description: Additionally, the activation of nuclear NF-?B (nuclear factor ?-light-chainenhancer of activated B cells) signaling pathway was repressed by GDF11 treatment. Collectively, GDF11 may represent a promising molecular target for the prevention and treatment of psoriasis-like skin inflammation.

About Function

Enhancer function : Additionally, the activation of nuclear NF-?B (nuclear factor ?-light-chainenhancer of activated B cells) signaling pathway was repressed by GDF11 treatment. Collectively, GDF11 may represent a promising molecular target for the prevention and treatment of psoriasis-like skin inflammation.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 Additionally, the activation of nuclear NF-?B (nuclear factor ?-light-chainenhancer of activated B cells) signaling pathway was repressed by GDF11 treatment. Collectively, GDF11 may represent a promising molecular target for the prevention and treatment of psoriasis-like skin inflammation.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
GDF11 BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 34
GDF11 Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) inoh 228
GDF11 Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) inoh 239
GDF11 Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) inoh 237
GDF11 Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) inoh 227
GDF11 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) inoh 228
GDF11 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) inoh 227
GDF11 TGF-beta signaling pathway panther 88
GDF11 TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 51

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs