About Enhancer
| Enhancer ID: | E_01_0106 |
| Species: | human |
| Position : | chr3:12284215-12286215   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Traumatic sepsis |
| Pubmed ID: | 31888703 |
| Enhancer experiment: | Western blot, dual luciferase gene reporter |
| Enhancer experiment description: | Enhancer polymorphism rs10865710 associated with traumatic sepsis is a regulator of PPARG gene expression |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Enhancer polymorphism rs10865710 associated with traumatic sepsis is a regulator of PPARG gene expression |
About TF
| TF name : | PPARG |
| TF experiment: | Western blot?????????? |
| TF experiment description: | Enhancer polymorphism rs10865710 associated with traumatic sepsis is a regulator of PPARG gene expression |
About Function
| Enhancer function : | Enhancer polymorphism rs10865710 associated with traumatic sepsis is a regulator of PPARG gene expression |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Enhancer polymorphism rs10865710 associated with traumatic sepsis is a regulator of PPARG gene expression |
About SNP
| SNP ID: | rs10865710 |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PPARG | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| PPARG | Noncanonical Wnt signaling pathway | pid | 33 |
| PPARG | Nuclear Receptor transcription pathway | reactome | 51 |
| PPARG | PPARA activates gene expression | reactome | 113 |
| PPARG | Regulation of retinoblastoma protein | pid | 67 |
| PPARG | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| PPARG | Signaling events mediated by HDAC Class I | pid | 89 |
| PPARG | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| PPARG | Wnt | netpath | 118 |
| PPARG | PPAR signaling pathway | kegg | 67 |
| PPARG | Huntington's disease | kegg | 182 |
| PPARG | Pathways in cancer | kegg | 321 |
| PPARG | Thyroid cancer | kegg | 25 |
| PPARG | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| PPARG | Hs_p38_MAPK_Signaling_Pathway_WP400_72084 | wikipathways | 28 |
| PPARG | Hs_Nucleotide_Metabolism_WP404_68960 | wikipathways | 16 |
| PPARG | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene