About Enhancer
| Enhancer ID: | E_01_0097 |
| Species: | human |
| Position : | chr5:1250197-1252197   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Neuroblastoma |
| Pubmed ID: | 31900258 |
| Enhancer experiment: | Chip qPCR, RT qPCR, Western blot, cell viability assay |
| Enhancer experiment description: | Epigenetically cotargeting Brd4 and Cdks suppresses human neuroblastoma with TERT overexpression by inhibiting the TERT-associated gene expression networks. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Epigenetically cotargeting Brd4 and Cdks suppresses human neuroblastoma with TERT overexpression by inhibiting the TERT-associated gene expression networks. |
About TF
| TF name : | TERT |
| TF experiment: | ChIPqPCR?RT-qPCR?Western blot??????? |
| TF experiment description: | Epigenetically cotargeting Brd4 and Cdks suppresses human neuroblastoma with TERT overexpression by inhibiting the TERT-associated gene expression networks. |
About Function
| Enhancer function : | Epigenetically cotargeting Brd4 and Cdks suppresses human neuroblastoma with TERT overexpression by inhibiting the TERT-associated gene expression networks. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Epigenetically cotargeting Brd4 and Cdks suppresses human neuroblastoma with TERT overexpression by inhibiting the TERT-associated gene expression networks. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TERT | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| TERT | HIF-1-alpha transcription factor network | pid | 67 |
| TERT | IL2 | netpath | 81 |
| TERT | IL2 signaling events mediated by PI3K | pid | 38 |
| TERT | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| TERT | Regulation of Telomerase | pid | 70 |
| TERT | Telomere Extension By Telomerase | reactome | 6 |
| TERT | Validated targets of C-MYC transcriptional activation | pid | 80 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene