About Enhancer
| Enhancer ID: | E_01_0075 |
| Species: | human |
| Position : | chr7:87500277-87502277   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Neutropenia |
| Pubmed ID: | 27845419 |
| Enhancer experiment: | Enhancer Assay |
| Enhancer experiment description: | These results suggest that genetic variation in ABCC1 and ABCB1 may contribute to irinotecan-induced neutropenia by altering expression of transporters involved in irinotecan metabolite disposition. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | These results suggest that genetic variation in ABCC1 and ABCB1 may contribute to irinotecan-induced neutropenia by altering expression of transporters involved in irinotecan metabolite disposition. |
About TF
| TF name : | ABCB1 |
| TF experiment: | Enhancer Assay |
| TF experiment description: | These results suggest that genetic variation in ABCC1 and ABCB1 may contribute to irinotecan-induced neutropenia by altering expression of transporters involved in irinotecan metabolite disposition. |
About Function
| Enhancer function : | These results suggest that genetic variation in ABCC1 and ABCB1 may contribute to irinotecan-induced neutropenia by altering expression of transporters involved in irinotecan metabolite disposition. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
These results suggest that genetic variation in ABCC1 and ABCB1 may contribute to irinotecan-induced neutropenia by altering expression of transporters involved in irinotecan metabolite disposition. |
About SNP
| SNP ID: | rs12720066,rs6498588 |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene