ENdb-Search-Detail

About Enhancer

Enhancer ID:	E_01_0043
Species:	human
Position :	chr15:99562705-99564705
Biosample name:
Experiment class :	High+Lowthroughput
Enhancer type:	Enhancer
Disease:	Placenta-related pregnancy disorders
Pubmed ID:	29127222
Enhancer experiment:	Transfection,Immunofluorescence,Western blot,ChIP,RT-PCR
Enhancer experiment description:	These findings suggest individual members of MEF2 family distinctively regulate 40 cytotrophoblast proliferation, invasion, and differentiation.

Target gene :	MEF2B,MEF2D
Strong evidence:	qRT-PCR,qPCR,ChIP,3C
Less strong evidence:	RNA-Seq
Target gene experiment description:	These findings suggest individual members of MEF2 family distinctively regulate 40 cytotrophoblast proliferation, invasion, and differentiation.;These findings suggest individual members of MEF2 family distinctively regulate 40 cytotrophoblast proliferation, invasion, and differentiation.;These findings suggest individual members of MEF2 family distinctively regulate 40 cytotrophoblast proliferation, invasion, and differentiation.;These findings suggest individual members of MEF2 family distinctively regulate 40 cytotrophoblast proliferation, invasion, and differentiation.

TF name :	MEF2A(A430079H05Rik)MEF2C(5430401D19Rik,9930028G15Rik,AV011172,Mef2)
TF experiment:	Transfection,Immunofluorescence,Western blot,ChIP,RT-PCR
TF experiment description:	These findings suggest individual members of MEF2 family distinctively regulate 40 cytotrophoblast proliferation, invasion, and differentiation.;These findings suggest individual members of MEF2 family distinctively regulate 40 cytotrophoblast proliferation, invasion, and differentiation.;These findings suggest individual members of MEF2 family distinctively regulate 40 cytotrophoblast proliferation, invasion, and differentiation.;These findings suggest individual members of MEF2 family distinctively regulate 40 cytotrophoblast proliferation, invasion, and differentiation.

Enhancer function :	These findings suggest individual members of MEF2 family distinctively regulate 40 cytotrophoblast proliferation, invasion, and differentiation.
Enhancer function experiment:	Immunohistochemical staining
Enhancer function experiment description:	These findings suggest individual members of MEF2 family distinctively regulate 40 cytotrophoblast proliferation, invasion, and differentiation.

SNP ID:

GeneName	Pathway Name	Source	Gene Number
MEF2A	CDO in myogenesis	reactome	29
MEF2A	ERK/MAPK targets	reactome	17
MEF2A	Signaling mediated by p38-alpha and p38-beta	pid	35
MEF2A	TGF_beta_Receptor	netpath	220
MEF2A	Hs_p38_MAPK_Signaling_Pathway_WP400_72084	wikipathways	28
MEF2C	CDO in myogenesis	reactome	29
MEF2C	Circadian Clock	reactome	49
MEF2C	ErbB1 downstream signaling	pid	105
MEF2C	ERK/MAPK targets	reactome	17
MEF2C	Notch	netpath	76
MEF2C	Oxidative stress response	panther	23
MEF2C	p38 MAPK pathway	panther	31
MEF2C	Regulation of nuclear SMAD2/3 signaling	pid	82
MEF2C	Regulation of retinoblastoma protein	pid	67
MEF2C	Signaling events mediated by HDAC Class II	pid	58
MEF2C	Signaling mediated by p38-alpha and p38-beta	pid	35
MEF2C	TGF_beta_Receptor	netpath	220
MEF2C	Transcriptional activation of mitochondrial biogenesis	reactome	43
MEF2C	Trk receptor signaling mediated by the MAPK pathway	pid	34
MEF2C	MAPK signaling pathway	kegg	264
MEF2C	Hs_Endochondral_Ossification_WP474_87977	wikipathways	43
MEF2C	Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000	wikipathways	153
MEF2C	Hs_Heart_Development_WP1591_90186	wikipathways	28
MEF2C	Hs_Oxidation_by_Cytochrome_P450_WP43_84102	wikipathways	14
MEF2C	Hs_TGF-beta_Signaling_Pathway_WP366_90028	wikipathways	67

The number on yellow line represents the distance between enhancer and target gene